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Analyzing The Role Of A Protein Downregulated After Induction Of Filamentous Growth In Candida Albicans, Jazmine Vasquez, Ian Cleary, Derek P. Thomas

McNair Scholars Manuscripts

Candida albicans is a commensal fungus, normally living with its human host, however, it has the ability to cause invasive infection. Candida albicans is the fourth most frequent nosocomial infection affecting a vulnerable immunocompromised population. Candida albicans exhibits different morphologies including yeast, pseudohyphae, and hyphae. The varying morphological potential of this organism is a virulence trait. Because of this, research has focused on what drives activation of hyphal formation as well as what impedes it. During a filamentation assay, a novel observation pertaining to a subgroup of proteins being downregulated early after germination, was made. In this study, we constructed …