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Synergistic Inhibition Of Resistant Enterobacteriaceae Using A Possible Klebsiella Secreted Bacteriocin With Broad-Spectrum Antibiotic, Andrew Robbins
Synergistic Inhibition Of Resistant Enterobacteriaceae Using A Possible Klebsiella Secreted Bacteriocin With Broad-Spectrum Antibiotic, Andrew Robbins
Undergraduate Honors Theses
Due to the increasing prevalence of multi-drug resistant (MDR) bacteria, it is now important to begin the search for novel means of defending against such resistant infections. Enterobacteriaceae is a clinically relevant family of bacteria that has shown extensive resistance to many antibiotics, especially after biofilm formation. Inhibitory poly-microbial interactions within this family have been observed. It is known that Citrobacter freundii (CF) growth is significantly inhibited by Klebsiella pneumoniae (KP) through a secreted protein. In this study, the potential KP bacteriocin was screened for its inhibitory effects on CF at various phases of biofilm development. The suspected KP bacteriocin …