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Full-Text Articles in Life Sciences

Topical Lipophilic Epigallocatechin-3-Gallate On Herpes Labialis: A Phase Ii Clinical Trial Of Averteax Formula, Man Zhao, Rong Zheng, Jinyan Jiang, Douglas Dickinson, Baiping Fu, Tin-Chun Chu, Lee Lee, Hanna Pearl, Stephen Hsu Sep 2015

Topical Lipophilic Epigallocatechin-3-Gallate On Herpes Labialis: A Phase Ii Clinical Trial Of Averteax Formula, Man Zhao, Rong Zheng, Jinyan Jiang, Douglas Dickinson, Baiping Fu, Tin-Chun Chu, Lee Lee, Hanna Pearl, Stephen Hsu

Tin-Chun Chu, Ph.D.

Objectives The aim of this study was to clinically evaluate a topical proprietary formulation containing lipophilic catechins (AverTeaX) on recurrent herpes labialis. Methods A double blind, placebo-controlled, randomized trial with 40 participants initially in two groups. Results Compared to the vehicle group, AverTeaX applied topically 6-8 times daily resulted in a significant reduction of clinical episode duration (median 4.5 days, range 1-11 days vs. 9 days, range 2-11 days, p=0.003) and shortened blistering/ulceration stages within an episode from a median of 3 (range 0-6) days to 1 (range 0-3) day (p=0.0003). Median quality of life scores based on a multi-question …


Antiviral Activity Of Theaflavin Digallate Against Herpes Simplex Virus Type 1, Aline De Oliveira, Derek Prince, Chih-Yu Lo, Lee Lee, Tin-Chun Chu May 2015

Antiviral Activity Of Theaflavin Digallate Against Herpes Simplex Virus Type 1, Aline De Oliveira, Derek Prince, Chih-Yu Lo, Lee Lee, Tin-Chun Chu

Tin-Chun Chu, Ph.D.

Tea is the second most consumed drink in the world. The beneficial effects of tea have been mostly attributed to its catechin content. Black tea is derived from the leaves of Camellia sinensis plant, and it is rich in theaflavin polyphenols, in particular theaflavin (TF1), theaflavin-3-monogallate (TF2A), theaflavin-3′-monogallate (TF2B), and theaflavin-3,3′-digallate (TF3). Vero and A549 cells were used to evaluate the effect of purified individual black tea theaflavins as anti-herpes simplex virus 1 agents. With the rise of HSV resistant strains, there is a critical need to develop novel antiherpesviral treatments. Results of the cytotoxicity assay tested by MTS [3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxy-phenyl)-2-(4-sulfophenyl)-2H-tetrazolium] …


Bloom-Forming Cyanobacteria And Other Phytoplankton In Northern New Jersey Freshwater Bodies, Tin-Chun Chu, Matthew Rienzo Jan 2013

Bloom-Forming Cyanobacteria And Other Phytoplankton In Northern New Jersey Freshwater Bodies, Tin-Chun Chu, Matthew Rienzo

Tin-Chun Chu, Ph.D.

No abstract provided.


Adaption Of Synechococcus Sp. Iu 625 To Growth In The Presence Of Mercuric Chloride, Tin-Chun Chu, Sean Murray, Jennifer Todd, Winder Perez, Jonathan Yarborough, Chiedozie Okafor, Lee Lee Dec 2011

Adaption Of Synechococcus Sp. Iu 625 To Growth In The Presence Of Mercuric Chloride, Tin-Chun Chu, Sean Murray, Jennifer Todd, Winder Perez, Jonathan Yarborough, Chiedozie Okafor, Lee Lee

Tin-Chun Chu, Ph.D.

No abstract provided.


Temperature-Induced Activation Of Freshwater Cyanophage As-1 Prophage., Tin-Chun Chu, Sean Murray, Shi-Fang Hsu, Quinn Vega, Lee Lee Apr 2011

Temperature-Induced Activation Of Freshwater Cyanophage As-1 Prophage., Tin-Chun Chu, Sean Murray, Shi-Fang Hsu, Quinn Vega, Lee Lee

Tin-Chun Chu, Ph.D.

No abstract provided.


Effects Of Oral Consumption Of The Green Tea Polyphenol Egcg In A Murine Model For Human Sjogren's Syndrome, An Autoimmune Disease., K. Gillespie, I. Kodani, D. Dickinson, K. Ogbureke, A. Camba, M. Wu, S. Looney, Tin-Chun Chu, H. Qin, F. Bisch, M. Sharawy, G. Schuster, S. Hsu Sep 2008

Effects Of Oral Consumption Of The Green Tea Polyphenol Egcg In A Murine Model For Human Sjogren's Syndrome, An Autoimmune Disease., K. Gillespie, I. Kodani, D. Dickinson, K. Ogbureke, A. Camba, M. Wu, S. Looney, Tin-Chun Chu, H. Qin, F. Bisch, M. Sharawy, G. Schuster, S. Hsu

Tin-Chun Chu, Ph.D.

No abstract provided.


Induction Of Temperate Cyanophage As-1 By Heavy Metal - Copper, Lee Lee, Lui Doris, Patricia Platner, Shi-Fang Hsu, Tin-Chun Chu, John Gaynor, Quinn Vega, Bonnie Lustigman Jan 2006

Induction Of Temperate Cyanophage As-1 By Heavy Metal - Copper, Lee Lee, Lui Doris, Patricia Platner, Shi-Fang Hsu, Tin-Chun Chu, John Gaynor, Quinn Vega, Bonnie Lustigman

Tin-Chun Chu, Ph.D.

No abstract provided.


Bioinformatic Analysis Of The Metal-Binding Protein Families And Heavy Metal Resistance Amongst Cyanobacteria, Tin-Chun Chu, Lee Lee, Shankar Srinivasan Dec 2004

Bioinformatic Analysis Of The Metal-Binding Protein Families And Heavy Metal Resistance Amongst Cyanobacteria, Tin-Chun Chu, Lee Lee, Shankar Srinivasan

Tin-Chun Chu, Ph.D.

No abstract provided.