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Insights Into The Reactivation, Regulation And Essentiality Of Oxidative Protein Folding Pathways In Actinobacteria, Belkys Sanchez

Dissertations & Theses (Open Access)

Accurate disulfide bond formation is important for proper folding, stability and function of exported proteins. The process of disulfide bond formation, termed oxidative protein folding, is catalyzed by thiol-disulfide oxidoreductase enzymes. Oxidative protein folding pathways influence processes essential for bacterial physiology and pathogenicity. In the Gram-positive actinobacterial pathogens Actinomyces oris and Corynebacterium diphtheriae oxidative protein folding is catalyzed by the primary thiol-disulfide oxidoreductase MdbA. MdbA is required for assembly of adhesive pilus, which mediate receptor-dependent bacterial interactions, or coaggregation, in A. oris. In the first part of this dissertation, I identify components of the electron transport chain (ETC) required for …

Annual Ryegrass Toxicity Research Update, A G P Brown, P. Vogal

Journal of the Department of Agriculture, Western Australia, Series 4

Annual ryegrass toxicity (ARGT) is a complex disease that kills sheep and cattle grazing pastures which contain infected ryegrass. The disease results when a nematode (Anguina agrostis) and a batcerium (Corynebacterium sp.) invade annual ryegrass and cause the seed heads to become toxic as the grass dries off.

The bacterium produces a complex toxin of 18 glycolipid compounds or corynetoxins which have been found to be virtually identical to the antibiotic tunicamycin.

Controlling Annual Ryegrass Toxicity, C H. Trotman

Journal of the Department of Agriculture, Western Australia, Series 4

Eight years of intensive work has changed annual ryegrass toxicity from an unknown killer to a manageable problem.

Ryegrass Disease Could Spread, Department Of Agriculture, Western Australia

Journal of the Department of Agriculture, Western Australia, Series 4

The disease annual ryegrass toxicity kills sheep and cattle grazing pastures which contain infected annual ryegrass. In Western Australia the first confirmed outbreak was in 1968 in the Gnowangerup area.

The disease has noe spread over a range of 450 kilometres and with a total area of perhaps 100 000 hectares. because annual ryegrass is the major sown pasture grass in W.A. the disease could spread throughout the South-West.

There are some precautions that can be taken.

Annual ('Wimmera') Ryegrass Toxicity, Geoffrey A. Pearce, O. M. Goss, P. H. Berry, J. L. Wise

Journal of the Department of Agriculture, Western Australia, Series 4

Because annual ryegrass is one of the most widespread pasture plants in Western Australia, annual ryegrass toxicity is a threat to livestock in many agricultural areas—even though the area now affected is small.

The problem is being intensively studied by the Department of Agriculture and a working group has been set up to investigate potential control measures.

In this article the group reviews the problem and reports progress in its investigations to the end of 1973.