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- Keyword
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- Brassica (2)
- Cruciferous (2)
- 4-methoxyglucobrassicin (PubChem CID: 656563) (1)
- ABCB5 (1)
- APP (1)
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- Accretion (1)
- Alliums (1)
- Amyloid-β (1)
- CYP1A1 (1)
- Campylobacter (1)
- Campylobacter concisus (1)
- Cancer (1)
- Cisplatin (1)
- Comorbidities (1)
- Gastritis (1)
- Glucobrassicanapin (PubChem CID: 5485207) (1)
- Glucobrassicin (PubChem CID: 5484743) (1)
- Glucoerucin (PubChem CID: 656539) (1)
- Glucoiberin (PubChem CID: 954862) (1)
- Gluconapin (PubChem CID: 9548620) (1)
- Gluconasturtiin (PubChem CID: 656555) (1)
- Glucoraphanin (PubChem CID: 9548634) (1)
- Glucosinolates (1)
- Human leukocyte antigen (HLA) (1)
- Immune response (1)
- Immunosuppression (1)
- Immunotherapies (1)
- Kidney injury (1)
- LC-MS (1)
- Larval mosquito development (1)
Articles 1 - 8 of 8
Full-Text Articles in Life Sciences
Development Of A Food Composition Database For The Estimation Of Dietary S-Methyl Cysteine Sulfoxide From Vegetables, Caroline R. Hill, Emma L. Connolly, Armaghan Shafaei, Lois Balmer, Liezhou Zhong, Taulant Muka, Antonietta Hayhoe, Shikha Saha, Richard J. Woodman, Joshua R. Lewis, Jonathan M. Hodgson, Lauren C. Blekkenhorst
Development Of A Food Composition Database For The Estimation Of Dietary S-Methyl Cysteine Sulfoxide From Vegetables, Caroline R. Hill, Emma L. Connolly, Armaghan Shafaei, Lois Balmer, Liezhou Zhong, Taulant Muka, Antonietta Hayhoe, Shikha Saha, Richard J. Woodman, Joshua R. Lewis, Jonathan M. Hodgson, Lauren C. Blekkenhorst
Research outputs 2022 to 2026
A food composition database estimating S-methyl cysteine sulfoxide (SMCSO) was created following a systematic literature search. SMCSO data (705 entries) from 19 vegetables were summarised: brassicas (n = 10) and alliums (n = 9). The highest SMCSO in brassicas was reported in Brussels sprouts (median [range]: 318 [68−420] mg/100 g fresh weight (FW)) whilst the lowest was in radish (19 [4–45] mg/100 g FW). Brussels sprouts were almost twice as concentrated in SMCSO as cauliflower, followed by cabbage, kale, broccoli, kohlrabi, swede, Chinese cabbage, and turnips. The alliums highest in SMCSO were Chinese chives (271 [185−413] mg/100 g FW) followed …
Simultaneous Extraction And Quantitative Analysis Of S-Methyl-L-Cysteine Sulfoxide, Sulforaphane And Glucosinolates In Cruciferous Vegetables By Liquid Chromatography Mass Spectrometry, Armaghan Shafaei, Caroline R. Hill, Jonathan M. Hodgson, Lauren C. Blekkenhorst, Mary C. Boyce
Simultaneous Extraction And Quantitative Analysis Of S-Methyl-L-Cysteine Sulfoxide, Sulforaphane And Glucosinolates In Cruciferous Vegetables By Liquid Chromatography Mass Spectrometry, Armaghan Shafaei, Caroline R. Hill, Jonathan M. Hodgson, Lauren C. Blekkenhorst, Mary C. Boyce
Research outputs 2022 to 2026
Sulfur containing compounds including glucosinolates (GLS), sulforaphane (SFN) and S-methyl-L-cysteine sulfoxide (SMCSO) have been proposed to be partly responsible for the beneficial health effects of cruciferous vegetables. As such, greater understanding of their measurements within foods is important to estimate intake in humans and to inform dietary intervention studies. Herein is described a simple and sensitive method for simultaneous analysis of 20 GLS, SFN and SMCSO by liquid chromatography mass spectrometry. Analytes were effectively retained and resolved on an Xbridge C18 column. Detection can be achieved using high resolution or unit resolution mass spectrometry; the latter making the method more …
Investigating The Genetic Makeup Of The Major Histocompatibility Complex (Mhc) In The United Arab Emirates Population Through Next-Generation Sequencing, Nour A. D. Marzouka, Halima Alnaqbi, Amira Al-Aamri, Guan Tay, Habiba Alsafar
Investigating The Genetic Makeup Of The Major Histocompatibility Complex (Mhc) In The United Arab Emirates Population Through Next-Generation Sequencing, Nour A. D. Marzouka, Halima Alnaqbi, Amira Al-Aamri, Guan Tay, Habiba Alsafar
Research outputs 2022 to 2026
The Human leukocyte antigen (HLA) molecules are central to immune response and have associations with the phenotypes of various diseases and induced drug toxicity. Further, the role of HLA molecules in presenting antigens significantly affects the transplantation outcome. The objective of this study was to examine the extent of the diversity of HLA alleles in the population of the United Arab Emirates (UAE) using Next-Generation Sequencing methodologies and encompassing a larger cohort of individuals. A cohort of 570 unrelated healthy citizens of the UAE volunteered to provide samples for Whole Genome Sequencing and Whole Exome Sequencing. The definition of the …
Quantitative Comparison Of Presenilin Protein Expression Reveals Greater Activity Of Ps2-Γ-Secretase, Melissa K. Eccles, Nathan Main, Rodrigo Carlessi, Ayeisha M. Armstrong, Miheer Sabale, Brigid Roberts-Mok, Janina E. E. Tirnitz-Parker, Mark Agostino, David Groth, Paul E. Fraser, Giuseppe Verdile
Quantitative Comparison Of Presenilin Protein Expression Reveals Greater Activity Of Ps2-Γ-Secretase, Melissa K. Eccles, Nathan Main, Rodrigo Carlessi, Ayeisha M. Armstrong, Miheer Sabale, Brigid Roberts-Mok, Janina E. E. Tirnitz-Parker, Mark Agostino, David Groth, Paul E. Fraser, Giuseppe Verdile
Research outputs 2022 to 2026
γ-secretase processing of amyloid precursor protein (APP) has long been of interest in the pathological progression of Alzheimer's disease (AD) due to its role in the generation of amyloid- . The catalytic component of the enzyme is the presenilins of which there are two homologues, Presenilin-1 (PS1) and Presenilin-2 (PS2). The field has focussed on the PS1 form of this enzyme, as it is typically considered the more active at APP processing. However, much of this work has been completed without appropriate consideration of the specific levels of protein expression of PS1 and PS2. We propose that expression is an …
Development Of A Regional Climate Change Model For Aedes Vigilax And Aedes Camptorhynchus (Diptera: Culicidae) In Perth, Western Australia, Kerry Staples, Peter J. Neville, Steven Richardson, Jacques Oosthuizen
Development Of A Regional Climate Change Model For Aedes Vigilax And Aedes Camptorhynchus (Diptera: Culicidae) In Perth, Western Australia, Kerry Staples, Peter J. Neville, Steven Richardson, Jacques Oosthuizen
Research outputs 2022 to 2026
Mosquito-borne disease is a significant public health issue and within Australia Ross River virus (RRV) is the most reported. This study combines a mechanistic model of mosquito development for two mosquito vectors; Aedes vigilax and Aedes camptorhynchus, with climate projections from three climate models for two Representative Concentration Pathways (RCPs), to examine the possible effects of climate change and sea-level rise on a temperate tidal saltmarsh habitat in Perth, Western Australia. The projections were run under no accretion and accretion scenarios using a known mosquito habitat as a case study. This improves our understanding of the possible implications of sea-level …
Immune Checkpoint Inhibitor Therapy For Advanced Cutaneous Squamous Cell Carcinoma In Australia: A Retrospective Real World Cohort Study, Luke S. Mclean, Annette M. Lim, Mathias Bressel, Jenny Lee, Rahul Ladwa, Alexander D. Guminski, Brett Hughes, Samantha Bowyer, Karen Briscoe, Samuel Harris, Craig Kukard, Rob Zielinski, Muhammad Alamgeer, Matteo Carlino, Jeremy Mo, John J. Park, Muhammad A. Khattak, Fiona Day, Danny Rischin
Immune Checkpoint Inhibitor Therapy For Advanced Cutaneous Squamous Cell Carcinoma In Australia: A Retrospective Real World Cohort Study, Luke S. Mclean, Annette M. Lim, Mathias Bressel, Jenny Lee, Rahul Ladwa, Alexander D. Guminski, Brett Hughes, Samantha Bowyer, Karen Briscoe, Samuel Harris, Craig Kukard, Rob Zielinski, Muhammad Alamgeer, Matteo Carlino, Jeremy Mo, John J. Park, Muhammad A. Khattak, Fiona Day, Danny Rischin
Research outputs 2022 to 2026
Objectives: To review the outcomes of immune checkpoint inhibitor (ICI) treatment of advanced cutaneous squamous cell carcinoma (CSCC) outside clinical trials. Study design: Retrospective observational study; review of patient records in fifteen Australian institutions. Setting, participants: All Australian adults with locally advanced or metastatic CSCC not amenable to curative surgery or radiotherapy treated with ICIs, 5 May 2017 – 23 May 2022, through a cemiplimab compassionate access scheme (Therapeutic Goods Administration Special Access Scheme) or who personally covered the cost of pembrolizumab prior to the start of the access scheme. Main outcome measures: Best overall response rate (ORR) according to …
Investigation Of Campylobacter Concisus Gastric Epithelial Pathogenicity Using Ags Cells, Christopher Y. M. Luk, Seul A. Lee, Nicholas Naidovski, Fang Liu, Alfred C. Y. Tay, Liang Wang, Stephen Riordan, Li Zhang
Investigation Of Campylobacter Concisus Gastric Epithelial Pathogenicity Using Ags Cells, Christopher Y. M. Luk, Seul A. Lee, Nicholas Naidovski, Fang Liu, Alfred C. Y. Tay, Liang Wang, Stephen Riordan, Li Zhang
Research outputs 2022 to 2026
Campylobacter concisus is an oral bacterium. Recent studies suggest that C. concisus may be involved in human gastric diseases. The mechanisms, however, by which C. concisus causes human gastric diseases have not been investigated. Here we examined the gastric epithelial pathogenicity of C. concisus using a cell culture model. Six C. concisus strains and the human gastric epithelial cell line AGS cells were used. IL-8 produced by AGS cells after incubation with C. concisus was measured using enzyme-linked immunosorbent assay (ELISA), and AGS cell apoptosis was determined by caspase 3/7 activities. The effects of C. concisus on actin arrangement in …
Clinical-Grade Human Skin-Derived Abcb5+ Mesenchymal Stromal Cells Exert Anti-Apoptotic And Anti-Inflammatory Effects In Vitro And Modulate Mrna Expression In A Cisplatin-Induced Kidney Injury Murine Model, Erika Rendra, Adriana T. Crigna, Cristina Daniele, Carsten Sticht, Maike Cueppers, Mark A. Kluth, Christoph Ganss, Markus H. Frank, Norbert Gretz, Karen Bieback
Clinical-Grade Human Skin-Derived Abcb5+ Mesenchymal Stromal Cells Exert Anti-Apoptotic And Anti-Inflammatory Effects In Vitro And Modulate Mrna Expression In A Cisplatin-Induced Kidney Injury Murine Model, Erika Rendra, Adriana T. Crigna, Cristina Daniele, Carsten Sticht, Maike Cueppers, Mark A. Kluth, Christoph Ganss, Markus H. Frank, Norbert Gretz, Karen Bieback
Research outputs 2022 to 2026
Acute kidney injury (AKI) is characterized by a rapid reduction in renal function and glomerular filtration rate (GFR). The broadly used anti-cancer chemotherapeutic agent cisplatin often induces AKI as an adverse drug side effect. Therapies targeted at the reversal of AKI and its potential progression to chronic kidney disease or end-stage renal disease are currently insufficiently effective. Mesenchymal stromal cells (MSCs) possess diverse immunomodulatory properties that confer upon them significant therapeutic potential for the treatment of diverse inflammatory disorders. Human dermal MSCs expressing ATP-Binding Cassette member B5 (ABCB5) have shown therapeutic efficacy in clinical trials in chronic skin wounds or …