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Articles 1 - 4 of 4
Full-Text Articles in Life Sciences
Walking As Ontological Shifter: Thoughts In The Key Of Life, Bibi (Silvina) Calderaro
Walking As Ontological Shifter: Thoughts In The Key Of Life, Bibi (Silvina) Calderaro
Dissertations, Theses, and Capstone Projects
With walking as ontological shifter I pursue an alternative to the dominant modernist episteme that offers either/or onto-epistemologies of opposition and their reifying engagements. I propose this type of walking is an intentional turning towards a set of radical positions that, as integrative aesthetic and therapeutic practice, brings multiplicity and synchronicity to experience and being in an expanded sociality. This practice facilitates the conditions of possibility for recurring points of contact between the interiority perceived as ‘body’ and the exteriority perceived as ‘world.’ While making evident the self’s at once incoherence with it-self, it opens to a space beyond the …
Cognitive And Neurobiological Degeneration Of The Mental Lexicon In Primary Progressive Aphasia, Jet M. J. Vonk
Cognitive And Neurobiological Degeneration Of The Mental Lexicon In Primary Progressive Aphasia, Jet M. J. Vonk
Dissertations, Theses, and Capstone Projects
The ease with which we use the thousands of words in our vocabulary stands in stark contrast to our difficulty establishing how they are organized in our mind and brain. The breakdown of language due to cortical atrophy in primary progressive aphasia (PPA) creates conditions to study this organization at a cognitive and neurobiological level in that the three variants of this disease, namely non-fluent, logopenic, and semantic PPA, each bear their own signature of language-specific decline and cortical atrophy. As the impaired regions in each variant are linked to different lexical and semantic attributes of words, lexical decision performance …
Potential Modifications To Enzyme Replacement Therapy In Anderson-Fabry Disease, Mariam Meghdari
Potential Modifications To Enzyme Replacement Therapy In Anderson-Fabry Disease, Mariam Meghdari
Dissertations, Theses, and Capstone Projects
Mutations in the GLA gene that encodes the lysosomal enzyme α-galactosidase A (αGal) result in the sphingolipidoses named Fabry disease. This enzymatic defect is inherited as an X-linked recessive disorder and is associated with a progressive deposition of glycosphingolipids, including globotriaosylceramide (GB3), galabioasylceramide, and blood group B substance in the cell. In affected males, and in some females, this leads to early death due to occlusive disease of the heart, kidney, and brain. This disease is currently treated by infusions of αGal, prolonging patients’ lives but producing antibodies against the enzyme reducing the treatment efficacy. Treatment also causes numerous and …
Naturally-Derived Molecular Ensembles In Medicine, Materials Science And Evolutionary Biology: An Interdisciplinary Study, Silvio Panettieri
Naturally-Derived Molecular Ensembles In Medicine, Materials Science And Evolutionary Biology: An Interdisciplinary Study, Silvio Panettieri
Dissertations, Theses, and Capstone Projects
The first chapter will introduce the work carried out in collaboration with the Govind laboratory at CCNY. Our quest was set forth to investigate the intimate relationship lying between chronic inflammation and tumor development. For at least the last fifteen years much research has been conducted on this topic; yet, the level of complexity arising from exceedingly interwoven biochemical pathways in mammals has resulted in slow advancements in this field. This is why we resorted to a simple yet powerful immunogenetic model organism, the fruit fly Drosophila melanogaster, in combination with the administration of the most common anti-inflammatory drug, …