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Assessment Of R18, Cog1410, And App96-110 In Excitotoxicity And Traumatic Brain Injury, Li Shan Chiu, Ryan S. Anderton, Jane L. Cross, Vince W. Clark, Adam B. Edwards, Neville W. Knuckey, Bruno P. Meloni
Assessment Of R18, Cog1410, And App96-110 In Excitotoxicity And Traumatic Brain Injury, Li Shan Chiu, Ryan S. Anderton, Jane L. Cross, Vince W. Clark, Adam B. Edwards, Neville W. Knuckey, Bruno P. Meloni
Health Sciences Papers and Journal Articles
Cationic arginine-rich and poly-arginine peptides (referred to as CARPs) have potent neuroprotective properties in in vitro excitotoxicity and in vivo models of stroke. Traumatic brain injury (TBI) shares many pathophysiological processes as stroke, including excitotoxicity. Therefore, we evaluated our lead peptide, poly-arginine R18, with the COG1410 and APP96-110 peptides, which have neuroprotective actions following TBI. In an in vitro cortical neuronal glutamic acid excitotoxicity injury model, R18 was highly neuroprotective and reduced neuronal calcium influx, while COG1410 and APP96-110 displayed modest neuroprotection and were less effective at reducing calcium influx. In an impact-acceleration closed-head injury model (Marmarou model), R18, COG1410, …