Life Sciences Commons^™

Cardiovascular Risk, Remote Ischemic Postconditioning, And Endothelial Ischemia-Reperfusion Injury, Brian A. Hemenway

Electronic Theses and Dissertations

Remote ischemic postconditioning (rIpost) is a potent vasculoprotective stimulus that is thought to reduce reperfusion injury associated with heart disease. However, certain animal models of cardiometabolic risk factors such as dyslipidemia, diabetes, and hypertension suggest the beneficial effects of rIpost to lessen reperfusion injury may be diminished. These findings have not been studied in clinically relevant humans. The aim of this study was to determine whether the protective effects of rIpost are reduced in the context of raised cardiometabolic risk in humans. Seven participants with raised cardiometabolic risk burden (age:57±7 years; BMI: 31±4kgm²participated in this 2X2 randomized cross-over …