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Full-Text Articles in Life Sciences
The Role Of Actin Polymerization In The Development Of The Fetal Vertebrate Heart During S-Looping, Kevan Benn
The Role Of Actin Polymerization In The Development Of The Fetal Vertebrate Heart During S-Looping, Kevan Benn
Honors Theses
Research on fetal cardiac looping is an important because cardiac looping is the first organ to undergo asymmetrical organogenesis. As well, birth defects occur due to errors in the development process, of which congenital heart defects are very common. Most heart defects begin in the looping process that preludes the shape of a mature heart. Therefore, research into heart looping can give light to how these defects develop. The looping process, which occurs between 30 and 56 hours post incubation (stage 10-16 in development), is divided into two processes. The first process, C-looping, is the process where the heart tube, …
Regulation Of Protein Degradation In The Heart By Amp-Activated Protein Kinase, Kedryn K. Baskin, Kedryn K. Baskin
Regulation Of Protein Degradation In The Heart By Amp-Activated Protein Kinase, Kedryn K. Baskin, Kedryn K. Baskin
Dissertations & Theses (Open Access)
The degradation of proteins by the ubiquitin proteasome system is essential for cellular homeostasis in the heart. An important regulator of metabolic homeostasis is AMP-activated protein kinase (AMPK). During nutrient deprivation, AMPK is activated and intracellular proteolysis is enhanced through the ubiquitin proteasome system (UPS). Whether AMPK plays a role in protein degradation through the UPS in the heart is not known. Here I present data in support of the hypothesis that AMPK transcriptionally regulates key players in the UPS, which, under extreme conditions can be detrimental to the heart. The ubiquitin ligases MAFbx /Atrogin-1 and MuRF1, key regulators of …