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Full-Text Articles in Life Sciences
Transcriptional Regulation Of Profilin Is Required For Drosophila Larval Wound Closure, Amanda Brock
Transcriptional Regulation Of Profilin Is Required For Drosophila Larval Wound Closure, Amanda Brock
Dissertations & Theses (Open Access)
Injury is an inevitable part of life, making wound healing essential for survival. In postembryonic skin, wound closure requires that epidermal cells recognize the presence of a gap and change their behavior to migrate across it. In Drosophila larvae, wound closure requires two signaling pathways (the Jun N-terminal kinase (JNK) pathway and the Pvr receptor tyrosine kinase signaling pathway) and regulation of the actin cytoskeleton. In this and other systems, it remains unclear how the signaling pathways that initiate wound closure connect to the actin regulators that help execute wound- induced cell migrations. Here we show that chickadee, which encodes …
Rok And Rac Mediation Of Prl-1 Function In The Wings Of Drosophila Melanogaster, Rosemary Dinkins
Rok And Rac Mediation Of Prl-1 Function In The Wings Of Drosophila Melanogaster, Rosemary Dinkins
Honors Program Theses
By the time a cancer metastasizes it has reached its most deadly stage. It therefore is essential that the underpinning mechanisms promoting metastasis are understood. Phosphatases of regenerating liver (PRL) have been repeatedly connected to cancer metastasis when overexpressed. However, little is yet known about the normal PRL function and biological pathways let alone the PRL pathway promoting metastasis. The current study explores the relationship between PRL-1 and two other genes, ROK and Rac,that have also been implicated in cell migration and metastasis. Increased PRL-1 function in conjunction with increased or decreased Rac function was forced to the dorsal half …