Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 4 of 4
Full-Text Articles in Life Sciences
Modulation Of Anti-Tumor Immune Response By Tgf-Β-Inducible Early Gene 1 (Tieg1), Andi Cani
Modulation Of Anti-Tumor Immune Response By Tgf-Β-Inducible Early Gene 1 (Tieg1), Andi Cani
Wayne State University Theses
Cancer immunotherapy has had limited clinical efficacy partly because regulatory T cells (Treg) suppress the immune response to tumor-associated antigens. Inducible regulatory T cells (iTreg), which are converted from naïve CD4 T cells by TGF-β, an abundant cytokine in the tumor microenvironment, may contribute to this immune suppression. Induction of Foxp3 by TGF-β is mediated by the transcription factor TIEG1 and abrogation of this protein prevents Foxp3 expression. We are testing the hypothesis that blockade of TIEG1 to prevent iTreg conversion will enhance immune response in DNA vaccination to the tumor associated antigen Her-2. Wild type and TIEG1 knockout mice …
The Use Of Metabolomics To Investigate Biomarker Profiles As Potential Early Risk Factors For Development Of Type Ii Diabetes Mellitus, Jennelle Lynn Arnew (Getty)
The Use Of Metabolomics To Investigate Biomarker Profiles As Potential Early Risk Factors For Development Of Type Ii Diabetes Mellitus, Jennelle Lynn Arnew (Getty)
Wayne State University Theses
ABSTRACT
THE USE OF METABOLOMICS TO INVESTIGATE BIOMARKERS PROFILES AS POTENTIAL EARLY RISK FACTORS FOR DEVELOPMENT OF TYPE II DIABETES
by
JENNELLE ARNEW
MAY 2012
Advisor: Dr. Smiti Gupta
Major: Nutrition and Food Science
Degree: Masters of Science
Type 2 Diabetes affects an estimated 17.5 million individuals in the United States and is considered to be one of the most pressing public health issues of our time. To date, the exact cause of type 2 diabetes remains unclear, however, it is considered to be an interplay between environmental and genetic factors. Emerging technologies for metabolomics analysis increases the capacity to …
Purification Of Alpha-Glucosidase Inhibitors From Grape Extract, Gayle M. Shipp
Purification Of Alpha-Glucosidase Inhibitors From Grape Extract, Gayle M. Shipp
Wayne State University Theses
ABSTRACT
PURIFICATION OF ALPHA-GLUCOSIDASE INHIBITORS FROM GRAPE EXTRACT
by
GAYLE SHIPP
August 2012
Advisor: Dr. Kevin Zhou
Major: Nutrition and Food Science
Degree: Master of Science
Diabetes and its complications are steadily growing and remain major causes of morbidity and mortality in the U.S. Intestinal á-glucosidases play a crucial role in controlling postprandial blood glucose. For this reason, one attractive prevention and/or treatment strategy for type-2 diabetes is the inhibition of á-glucosidase. The effectiveness of á-glucosidase inhibitors (AGI's) for diabetes treatment is well documented in numerous animal and human clinical studies. Grape pomace extract (GPE) has recently found in our …
The Effects Of Oil Palm Phenolics On Inflammation And Oxidative Stress In Relation To Amyloid Beta Plaques In Fad-Mutant And Wild Type B103 Cells, Lindsay Michelle Godsey
The Effects Of Oil Palm Phenolics On Inflammation And Oxidative Stress In Relation To Amyloid Beta Plaques In Fad-Mutant And Wild Type B103 Cells, Lindsay Michelle Godsey
Wayne State University Theses
Alzheimer's disease (AD) affects approximately 35.6 million people in the world today (35). It is expected that by year 2050, an individual will develop AD every 33 seconds (8). Unfortunately, the etiology is not well known. Familial Alzheimer's disease (FAD) occurs due to specific genetic mutations, making it possible to replicate them in cells. Using B103 rat neuroblastoma cells transfected with a cDNA construct, wild type cells and FAD mutant cells were used in this research.
Natural ingredients such as oil palm phenolics (OPP) contain antioxidants. After finding the optimal experimental parameters, OPP was found to aid in the destabilization …