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Human Regulatory T Cells Control Inflammation From Effector T Cells In Prediabetes, Rui Liu
Human Regulatory T Cells Control Inflammation From Effector T Cells In Prediabetes, Rui Liu
Theses and Dissertations--Pharmacy
Type 2 diabetes (T2D) is a chronic low-grade inflammatory disease. A T cell cytokine profile (Th17) from PBMCs can distinguish obese T2D from obese non-diabetes subjects. Individual T cell subsets interact with each other and the diverse subsets jointly determine overall inflammation. Cellular metabolism drives cytokine production of CD4+ T cells, and therefore contributes to inflammation in T2D. However, specific changes in metabolism and function of CD4+ T cells during the progression from lean healthy to obese and diabetic stages in people have not been clarified.
We hypothesize that human regulatory T cells (Treg) impact metabolism of effector …