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Articles 1 - 6 of 6
Full-Text Articles in Life Sciences
Health Care Informatics Support Of A Simulated Study, Zeinab Salari Far
Health Care Informatics Support Of A Simulated Study, Zeinab Salari Far
Theses and Dissertations
The objective of this project is to assess the value of REDCap (Harris, 2009) by conducting a simulated breast cancer clinical trial and demonstration. REDCap is a free, secure, web-based application designed to support data capture for research studies. To assess REDCap's value, we conducted a simulation of a clinical trial study designed to compare the use of two new technologies for breast cancer diagnosis and treatment with current best practice breast cancer diagnosis and treatment. We call the trial, "Real-Time Operating Room BC Diagnostic Treatment (RORBCDT)". The RORBCDT clinical trial is designed to assess the value of a new …
A Systematic Framework For Radio Frequency Identification (Rfid) Hazard Mitigation In The Blood Transfusion Supply Chain From Donation To Distribution, Natalie Simone Rahming
A Systematic Framework For Radio Frequency Identification (Rfid) Hazard Mitigation In The Blood Transfusion Supply Chain From Donation To Distribution, Natalie Simone Rahming
Theses and Dissertations
The RFID Consortium is developing what will be the first FDA-approved use of radio frequency identification (RFID) technology to identify, track, manage, and monitor blood throughout the entire blood transfusion supply chain. The iTraceTM is an innovative technological system designed to optimize the procedures currently employed when tracing blood from the donor to the recipient. With all novel technologies it is essential to consider not only the advantages, but also the potential harms that may come about from using the system. The deployment of the iTraceTM consists of two phases: 1) Phase One - application of the iTraceTM from the …
Complexity And Uncertainty In Human And Ecological Risk Assessment, Matthew Jordan Dellinger
Complexity And Uncertainty In Human And Ecological Risk Assessment, Matthew Jordan Dellinger
Theses and Dissertations
Multiple interacting stressors in the environment present increasingly complex risks to human health. Too often, however, the data required for traditional risk assessment are either lacking or unavailable at the necessary spatial or temporal scale. In addition, assessment practices and management policies need to move away from single factor approaches in order to accommodate the reality of complex chemical mixtures and environmental stressors. Recent literature suggests that a paradigm shift is under way. This points to a need for the development of new techniques both for rapid data collection and flexible risk assessment strategies that can adapt to make use …
Role Of Interleukin-17 In The Adaptive Immune Response In Lyme Arthritis, Emily Siebers
Role Of Interleukin-17 In The Adaptive Immune Response In Lyme Arthritis, Emily Siebers
Theses and Dissertations
Lyme arthritis is a devastating symptom of Lyme borreliosis that causes severe inflammation of the synovial joints. Interleukin-17 (IL-17) plays a role in the pathogenesis of various arthritides, including, possibly, Lyme arthritis, by causing the expression of genes involved in the production of inflammatory cytokines by synoviocytes. However, the cellular sources of IL-17 in the context of Borrelia burgdorferi infection are unknown, as are the effects of these cells on the development of arthritis and stimulation of humoral immunity through the production of borreliacidal antibodies. Using multiple models of Lyme arthritis, the hypothesis that IL-17 produced by CD4+ cells contributes …
Development Of A Methodology For The Quantification Of Physiological Load For Soccer Players, Robert W. Wilson
Development Of A Methodology For The Quantification Of Physiological Load For Soccer Players, Robert W. Wilson
Theses and Dissertations
The overall aim of this research project was to devise valid mathematical models for quantifying the physiological load (PL) of practices and competitions for female and male NCAA Division I collegiate soccer players. Data from sub-maximal and maximal effort tests were used to construct these models. After development of the physiological load quantification (PLQ) models, the validity of them occurred by comparing them to the physiological gold standard of performed work, volume of oxygen consumed (V*O2). Last, comparisons of the scores from the PLQ models to the PL scores from the previous models occurred. In combination these three studies have …
Effects Of Physical Exertion And Alignment Alterations On Trans-Tibial Amputee Gait, And Concurrent Validity Of Prosthesis-Integrated Measurement Of Gait Kinetics, Goeran Fiedler
Theses and Dissertations
This study investigated the effects of slight changes in the alignment of the artificial limb of trans-tibial amputees on the walking pattern on the level of forces and moments, particularly when physical exertion levels increase. Two alignment conditions were assessed in ten trans-tibial amputees while walking with low and with "strong" levels of exertion. Two separate data collection methods were utilized simultaneously: a conventional motion analysis, and continuous recordings from prosthesis-integrated force sensors. While the former was used to compare bilateral leg symmetry across conditions, the latter allowed analyzing unilateral step variability within subjects. This paper presents both analyses in …