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The Tissue-Specific Nuclear Matrix Protein, Nmp-2, Is A Member Of The Aml/Cbf/Pebp2/Runt Domain Transcription Factor Family: Interactions With The Osteocalcin Gene Promoter, Harold Merriman, Andre Van Wijnen, Scott Hiebert, Joseph Bidwell, Edward Fey, Jane Lian, Janet Stein, Gary Stein
The Tissue-Specific Nuclear Matrix Protein, Nmp-2, Is A Member Of The Aml/Cbf/Pebp2/Runt Domain Transcription Factor Family: Interactions With The Osteocalcin Gene Promoter, Harold Merriman, Andre Van Wijnen, Scott Hiebert, Joseph Bidwell, Edward Fey, Jane Lian, Janet Stein, Gary Stein
Harold L. Merriman
The nuclear matrix protein, NMP-2, was originally identified as an osteoblast-specific DNA-binding complex localized exclusively to the nuclear matrix. NMP-2 was shown to recognize two binding sites, site A (nt-605 to -599) and site B (nt -441 to -435), in the rat bone-specific osteocalcin gene promoter. This study shows that the NMP-2 binding sites A and B as well as a third NMP-2 binding site (nt -135 to -130) constitute a consensus sequence, ATGCTGGT, and represent an AML-1 recognition motif. AML-1 is a member of the AML transcription factor family which is associated with acute myelogenous leukemia and binds to …