Life Sciences Commons^™

Effect Of Long-Term Dietary Fat Quality On Metabolic Health With A Special Focus On Dairy Fat, Allison L. Unger

Graduate College Dissertations and Theses

Diet, and particularly dietary fat quality (i.e., fatty acid composition), is a significant modifiable risk factor in the development of metabolic diseases. However, whether the manipulation of long-term dietary fat quality may serve as an effective dietary strategy to mitigate metabolic disease risk during aging is not well defined. Accordingly, this work sought to investigate the role of life-long consumption of bioactive fatty acids from various food sources, and particularly dairy fat, on health maintenance and metabolic disease risk later in life. To address this issue, I assessed how long-term supplementation of dairy fat (butter oil), echium oil, or fish …

The Role Of Infralimbic Cortex In Switching Between An Instrumental Behavior’S Status As A Goal-Directed Action Or Habit, Matthew Broomer

Graduate College Dissertations and Theses

In instrumental learning, extensive training of a response typically generates a habit. The transition from goal-directed to habitual behavioral control is often considered unidirectional; however, recent evidence suggests this is not the case. Under certain conditions, goal-directed control may be restored to a behavior that was previously habitual. We identify the infralimbic cortex (IL) as a participant in this process and draw on both instrumental learning and fear extinction literatures to further our understanding of IL function.

Four experiments explored the role of IL in flexible behavior. Experiments 1a and 1b were instrumental learning experiments. Experiment 1a used a previously …

Designer Biologics Composed Of Hepatocyte Growth Factor, Fibroblast Growth Factor 2 And Immunoglobulin G For Treatment Of Acute Myocardial Infarction, Benjamin Liebman

Graduate College Dissertations and Theses

ABSTRACT Coronary artery disease leading to myocardial infarction (a.k.a. MI, heart attack) is one of the leading causes of death globally. Each year an estimated 605,000 Americans suffer a heart attack, which equates to one MI every 40 seconds. As such, MI represents one of the largest health burdens to society. The current standard of care is revascularization therapy achieved by fibrinolytics and Percutaneous Coronary Intervention (PCI); both of which re-open occluded proximal arteries to restore blood flow to the affected areas. Despite revascularization therapy, 30-50% of patients exhibit a form of reperfusion injury termed “no/low-reflow” in which the blood …

Examining Sex Differences In Habit Formation: Effects Of Methamphetamine Sensitization And Contributions Of Ovarian Hormones, Hannah Schoenberg Book

Graduate College Dissertations and Theses

In the early stages of instrumental learning, behavior is goal-directed and sensitive to changes in the value of the instrumental outcome. As learning progresses, an association forms between the response and stimuli within the learning environment, such that after sufficient repetition, responding is evoked automatically in the presence of these stimuli and is insensitive to changes in outcome value. The reflexive nature of these types of behaviors has led to their classification as instrumental habits. The emergence of habitual behavior is thought to involve parallel processes that are mediated by distinct neural substrates. Regions of the prefrontal cortex, amygdala, and …

Microevolution In Staphylococcus Aureus: Does Exposure To Sub-Lethal Levels Of Cinnamon Bark Oil Lead To Changes In Antimicrobial Susceptibility?, Heather Sandra Schuettner

Graduate College Dissertations and Theses

The emergence of antibiotic-resistant and multi-drug resistant bacteria presents a growing global health issue recognized by the World Health Organization and the Centers for Disease Control and Prevention. Infections caused by drug-resistant bacteria are associated with longer hospital stays, higher treatments costs, and increased mortality compared to infections caused by antibiotic-susceptible pathogens. The global increase in antibiotic resistance is driven in part by the misuse and overuse of antibiotics in healthcare and agriculture. Staphylococcus aureus can infect humans and animals, and strains that are resistant to one or more antibiotics are common. Many plant essential oils have antimicrobial properties. Essential …

Microevolution In Staphylococcus Aureus: Does Exposure To Sub-Lethal Levels Of Cinnamon Bark Oil Lead To Changes In Antimicrobial Susceptibility?, Heather Sandra Schuettner

Graduate College Dissertations and Theses

The emergence of antibiotic-resistant and multi-drug resistant bacteria presents a growing global health issue recognized by the World Health Organization and the Centers for Disease Control and Prevention. Infections caused by drug-resistant bacteria are associated with longer hospital stays, higher treatments costs, and increased mortality compared to infections caused by antibiotic-susceptible pathogens. The global increase in antibiotic resistance is driven in part by the misuse and overuse of antibiotics in healthcare and agriculture. Staphylococcus aureus can infect humans and animals, and strains that are resistant to one or more antibiotics are common. Many plant essential oils have antimicrobial properties. Essential …