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Chronic Inflammatory Demyelinating Polyneuropathy (CIDP); peripheral nervous system; muscle; human; weakness; motor unit; electromyography (EMG); magnetic resonance imaging (MRI).
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The Effects Of Chronic Inflammatory Demyelinating Polyneuropathy On The Neuromuscular System In Humans, Kevin J. Gilmore
The Effects Of Chronic Inflammatory Demyelinating Polyneuropathy On The Neuromuscular System In Humans, Kevin J. Gilmore
Electronic Thesis and Dissertation Repository
Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) is an inflammatory autoimmune peripheral nerve disorder. CIDP is associated with demyelination, slow motor nerve-conduction velocity, and distal muscle weakness. CIDP is under-recognized due to its heterogeneous presentation and the limitations of clinical diagnostic criteria. Using a combination of electrophysiology and muscle imaging techniques the four studies outlined in this thesis systemically investigate the impacts of this demyelinating disease on motor nerves and their innervated muscles.
The first two studies examine the neuronal consequences of demyelination caused by CIDP and the following two studies investigate how skeletal muscle is affected by these neuronal complications. Specifically, …