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Dax-1 Gene Expression Regulation In Prostate Cancer Cells Through The Activation Of Androgen Receptors, Ryan Jann, Roxxana Beltran
Dax-1 Gene Expression Regulation In Prostate Cancer Cells Through The Activation Of Androgen Receptors, Ryan Jann, Roxxana Beltran
Creative Activity and Research Day - CARD
The nuclear hormone receptor DAX-1 (dosage-sensitive sex reversal, adrenal hypoplasia critical region, on chromosome X, gene 1) is associated with the development and progression of prostate cancer within human males. Previous studies on DAX-1 have suggested a repression of steroidogenesis, indicating an inverse correlation between DAX-1 and steroidogenic gene expressions. To further understand the role of DAX-1 in tumor growth and development, experimentation was performed on Androgen Receptor (AR) sensitive and insensitive prostate cancer cell lines. Analysis of the different gene expression patterns of prostate cancer cell lines (including a CRISPR DAX-1 negative cell line) under separate treatment conditions, provides …