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Silver Sulfadiazine’S Effect On Keratin-19 Expression As Stem Cell Marker In Burn Wound Healing, Dewi Sukmawati, Astheria Eryani, Lia Damayanti
Silver Sulfadiazine’S Effect On Keratin-19 Expression As Stem Cell Marker In Burn Wound Healing, Dewi Sukmawati, Astheria Eryani, Lia Damayanti
BioMedicine
Background: Burn wounds are one of the causes of cutaneous injury that involve both epidermal and dermal layers of skin. Silver sulfadiazine (SSD) has been widely used to treat burn wounds, however recent studies have found the treatment to have some drawbacks, such as cellular toxicity effects. Cutaneous wound regeneration is known to start from the basal layer of the epidermal epithelial cells, which are enriched with highly proliferative cells. Keratin-19 (K19) is one of the epidermal stem cell biomarkers found in the skin. This study aims to explore the expression of K19 in burn wound tissue and to …