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Mosaic Expression Of Atrx In The Mouse Central Nervous System Causes Memory Deficits, Renee J. Tamming, Jennifer R. Siu, Yan Jiang, Marco A. M. Prado, Frank Beier, Nathalie G. Berube

Anatomy and Cell Biology Publications

The rapid modulation of chromatin organization is thought to play a crucial role in cognitive processes such as memory consolidation. This is supported in part by the dysregulation of many chromatin-remodelling proteins in neurodevelopmental and psychiatric disorders. A key example is ATRX, an X-linked gene commonly mutated in individuals with syndromic and nonsyndromic intellectual disability. The consequences of Atrx inactivation for learning and memory have been difficult to evaluate because of the early lethality of hemizygous-null animals. In this study, we evaluated the outcome of brain-specific Atrx deletion in heterozygous female mice. These mice exhibit a mosaic pattern of ATRX …