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Soluble Bone-Derived Osteopontin Promotes Migration And Stem-Like Behavior Of Breast Cancer Cells, Graciella M. Pio, Ying Xia, Matthew M. Piaseczny, Jenny E. Chu, Alison L. Allan

Anatomy and Cell Biology Publications

Breast cancer is a leading cause of cancer death in women, with the majority of these deaths caused by metastasis to distant organs. The most common site of breast cancer metastasis is the bone, which has been shown to provide a rich microenvironment that supports the migration and growth of breast cancer cells. Additionally, growing evidence suggests that breast cancer cells that do successfully metastasize have a stem-like phenotype including high activity of aldehyde dehydrogenase (ALDH) and/or a CD44(+)CD24(-)phenotype. In the current study, we tested the hypothesis that these ALDH (hi) CD44 (+) CD24(-)breast cancer cells interact with factors in …