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Articles 1 - 10 of 10
Full-Text Articles in Life Sciences
Computational Prediction Of The Agregated Structure Of Denatured Lysozyme, Pongsathorn Chotikasemsri
Computational Prediction Of The Agregated Structure Of Denatured Lysozyme, Pongsathorn Chotikasemsri
Masters Theses & Specialist Projects
Mis-folded proteins and their associated aggregates are a contributing factor in some human diseases. In this study we used the protein lysozyme as a model to define aggregation structures under denaturing conditions. Sasahara et al. (2007), Frare et al. (2009, 2006), and Rubin et al. (2008) observed conditions where heat denatured lysozyme formed fibril structures that were observed to be 8-17 nanometers in diameter under the electron microscope. Even though the crystal structure of lysozyme is known, the denatured form of this protein is still unknown. Therefore, we used Rosetta++ protein folding and blind docking software to create in silico …
The Lyme Disease Spirochete, Borrelia Burgdorferi, In Tick Species Collected From Raccoons (Procyon Lotor) And Opossums (Didelphis Virginiana) Trapped In The Warren And Barren Counties Of South Central Kentucky, Kristina Tackett
Masters Theses & Specialist Projects
The incidence of tick-borne zoonoses such as Ehrlichiosis, Rocky Mountain Spotted Fever, and Lyme disease has steadily increased in the southeastern United States in recent years. According to the Centers for Disease Control and Prevention (CDC), the southeastern states accounted for 1,200 of the 27,000 total cases of Lyme disease reported in the U.S. in 2007. Although Ixodes scapularis is the most commonly recognized vector for the Lyme disease spirochete Borrelia burgdorferi, Dermacentor variabilis (a common vector for Rocky Mountain Spotted Fever) also has been shown to be a viable host for this pathogen. The purpose of the present …
The Effects Of Repeated Anaerobic Bouts On Immune Parameters, James C. Sivley
The Effects Of Repeated Anaerobic Bouts On Immune Parameters, James C. Sivley
Masters Theses & Specialist Projects
To date, the exercise-induced immune response in has only been evaluated in subjects performing aerobic exercise. The primary purpose of this study is to determine if repeated bouts of anaerobic exercise will induce a similar immune response in human subjects as exhibited by aerobic exercise. Secondary to immune function, an analysis of performance from trial to trial will be made. Nine males between the ages of 18-25 were selected on a volunteer basis to participate in this study. Subjects performed Wingate tests set in 3 series with 120 seconds between trials within series and 405 seconds between series for an …
Role Of Cd4+Cd25+ Regulatory T Lymphocytes In Experimental Toxoplasmosis, Sanjay Varikuti
Role Of Cd4+Cd25+ Regulatory T Lymphocytes In Experimental Toxoplasmosis, Sanjay Varikuti
Masters Theses & Specialist Projects
Toxoplasmosis is an important cause of congenital disease, and it is one of the most common opportunistic infections in patients with acquired immunodeficiency syndrome. The need for a reliable experimental model of this infection is crucial not only for achieving a better understanding of the patho-physiology of the disease, but also for developing better methods for evaluating new therapeutic regimens. The purpose of the present study was to investigate the role of CD4+CD25+ T regulatory lymphocytes in mice infected with Toxoplasma gondii. T regulatory (Treg) cells have been shown to play an important role in our immune system in …
The Effect Of Endothelin-1 On The Expression Of Cdk Inhibitors P21 & P27 In Bovine Corneal Endothelial Cells, Lakshmi Reddy Bollu
The Effect Of Endothelin-1 On The Expression Of Cdk Inhibitors P21 & P27 In Bovine Corneal Endothelial Cells, Lakshmi Reddy Bollu
Masters Theses & Specialist Projects
Mammalian corneal endothelial cells are considered to be non-proliferative due to the arrest of cells at the G1 phase of the cell cycle. The purpose of this study was to determine whether the down regulation of cyclin dependant kinase inhibitors (p21cip1 and p27kip1) levels by Endothelin-1 (ET-1), would overcome the G1 phase arrest and promote cell cycle progression and proliferation in cultured BCECs (Bovine corneal endothelial cells). BCECs were isolated from bovine corneas and cultured in DMEM supplemented with 10% serum. 5-Bromo 2-deoxy Uridine (BrdU) incorporation was determined in serum starved cultures in 24-well plates as a measure of cell …
Confidence Intervals For The Ratio Of Two Exponential Means With Applications To Quality Control, James Albert Polcer,Iii
Confidence Intervals For The Ratio Of Two Exponential Means With Applications To Quality Control, James Albert Polcer,Iii
Student Research Conference Select Presentations
We considered the problem of statistical quality control based on the ratio of two population means. We restrict the discussion for two exponential rates, which are commonly used for modeling failure times of components, machines, or systems. Closed form expressions via the moment generation function (MGF) technique will be presented, and numerical examples will be shown using engineering data sets.
Protecting Walden Pond: A Step Towards Defending Ordinary Nature In The United States, Jessie L. Magee
Protecting Walden Pond: A Step Towards Defending Ordinary Nature In The United States, Jessie L. Magee
Student Research Conference Select Presentations
No abstract provided.
Faulkner The Humanist: How His Nobel Prize Acceptance Speech Changed How We Interpret "Barn Burning", Jessie L. Magee
Faulkner The Humanist: How His Nobel Prize Acceptance Speech Changed How We Interpret "Barn Burning", Jessie L. Magee
Student Research Conference Select Presentations
No abstract provided.
39th Annual Wku Student Research Conference, Student Research Council, Western Kentucky University
39th Annual Wku Student Research Conference, Student Research Council, Western Kentucky University
Student Research Conference Select Presentations
No abstract provided.
Ua94/6/1 Student / Alumni Personal Papers Western Kentucky University Small Collections, Wku Archives
Ua94/6/1 Student / Alumni Personal Papers Western Kentucky University Small Collections, Wku Archives
WKU Archives Collection Inventories
Small collections of personal papers and oral histories relating to the Western Kentucky University.