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Effect Of High Amylose Maize Starches On Colonic Fermentation And Apoptotic Response To Dna-Damage In The Colon Of Rats, Ian L. Brown, Richard K. Le Leu, Graeme P. Young, Ying Hu
Effect Of High Amylose Maize Starches On Colonic Fermentation And Apoptotic Response To Dna-Damage In The Colon Of Rats, Ian L. Brown, Richard K. Le Leu, Graeme P. Young, Ying Hu
Faculty of Health and Behavioural Sciences - Papers (Archive)
Background
We investigated in rats the effects of feeding different forms of high amylose maize starches (HAMS) rich in resistant starch (RS) to understand what the implications of RS heterogeneity might be for colonic biology, including innate cellular responses to DNA-damage.
Methods
A range of maize starches were compared: digestible cornstarch (Control), HYLON® VII, Hi-maize® 1043, Hi-maize® 240, Hi-maize® 260 and NOVELOSE® 330. Included in the comparison was Cellulose. End-points after 4 weeks included: pH, short chain fatty acids (SCFA) levels, colonic epithelial cell kinetics and apoptotic response to carcinogen 'azoxymethane' in the colonic epithelium. …