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Full-Text Articles in Life Sciences
Long-Term Impact Of Mild Traumatic Brain Injuries On Multiple Functional Outcomes And Epigenetics: A Pilot Study With College Students, Hyunhwa Lee, Sungchul Lee, Ipuna Black, Laura Salado, Jonica Estrada, Katrina Isla
Long-Term Impact Of Mild Traumatic Brain Injuries On Multiple Functional Outcomes And Epigenetics: A Pilot Study With College Students, Hyunhwa Lee, Sungchul Lee, Ipuna Black, Laura Salado, Jonica Estrada, Katrina Isla
Nursing Faculty Publications
People who suffer a mild traumatic brain injury (mTBI) have heterogeneous symptoms and disease trajectories, which make it difficult to precisely assess long-term complications. This pilot study assessed and compared deficits in cognitive, psychosocial, visual functions, and balance performance between college students with and without histories of mTBI. Global DNA methylation ratio (5-mC%) in blood was also compared as a peripheral epigenetic marker. Twenty-five volunteers participated, including 14 healthy controls (64.3% females; mean age of 22.0) and 11 mTBI cases (27.3% females; mean age of 28.7 years) who self-reported mTBI history (63.6% multiple; 2.5 ± 1.29 injuries) with 7.1 years …
Scald Injury-Induced T Cell Dysfunction Can Be Mitigated By Gr1+ Cell Depletion And Blockage Of Cd47/Cd172a Signaling, Nadine Beckmann, Franziska Huber, Marc Hanschen, Barbara St. Pierre Schneider, Vanessa Nomelli, Charles C. Caldwell
Scald Injury-Induced T Cell Dysfunction Can Be Mitigated By Gr1+ Cell Depletion And Blockage Of Cd47/Cd172a Signaling, Nadine Beckmann, Franziska Huber, Marc Hanschen, Barbara St. Pierre Schneider, Vanessa Nomelli, Charles C. Caldwell
Nursing Faculty Publications
Infection is a common and severe complication of burn injury: Sepsis accounts for 47% of postburn mortality. Burn-induced T cell suppression likely contributes to the increased infection susceptibility in burn patients. However, little is known about the kinetics of T cell dysfunction after burn and its underlying mechanisms. In this study, we show in a murine scald injury model that T cell activation of both CD4+ and CD8+ T cells as well as T cell cytokine production is suppressed acutely and persistently for at least 11 days after burn injury. Purified T cells from scald-injured mice exhibit normal T cell …