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Articles 1 - 2 of 2
Full-Text Articles in Life Sciences
Long-Term Impact Of Changing Childhood Malnutrition On Rotavirus Diarrhoea: Two Decades Of Adjusted Association With Climate And Socio-Demographic Factors From Urban Bangladesh, Sumon Kumar Das, Mohammod Jobayer Chisti, Mohammad Habibur Rahman Sarker, Jui Das, Shawnawaz Ahmed, K. M. Shahunja, Shamsun Nahar, Nora Gibbons, Tahmeed Ahmed, Abu Syed Golam Faruque, Mustafizur Rahman, George J. Fuchs Iii, Abdullah Al Mamun, Peter John Baker
Long-Term Impact Of Changing Childhood Malnutrition On Rotavirus Diarrhoea: Two Decades Of Adjusted Association With Climate And Socio-Demographic Factors From Urban Bangladesh, Sumon Kumar Das, Mohammod Jobayer Chisti, Mohammad Habibur Rahman Sarker, Jui Das, Shawnawaz Ahmed, K. M. Shahunja, Shamsun Nahar, Nora Gibbons, Tahmeed Ahmed, Abu Syed Golam Faruque, Mustafizur Rahman, George J. Fuchs Iii, Abdullah Al Mamun, Peter John Baker
Pediatrics Faculty Publications
Background
There is strong association between childhood rotavirus, diarrhoea, climate factors and malnutrition. Conversely, a significant nutritional transition (reduced under-nutrition) with a concurrent increasing trend of rotavirus infection in last decade was also observed among under 5 children, especially in developing countries including Bangladesh. Considering the pathophysiology of rotavirus, there might be an interaction of this nutrition transition which plays a pivotal role in increasing rotavirus infection in addition to climate and other man-made factors in urban areas such as Dhaka, Bangladesh.
Methods
Relevant monthly data from 1993–2012 were extracted from the archive of the Diarrhoeal Disease Surveillance System of …
Neutralizing Anti-Interleukin-1Β Antibodies Reduce Ischemia-Related Interleukin-1Β Transport Across The Blood-Brain Barrier In Fetal Sheep, Aparna Patra, Xiaodi Chen, Grazyna B. Sadowska, Jiyong Zhang, Yow-Pin Lim, James F. Padbury, William A. Banks, Barbara S. Stonestreet
Neutralizing Anti-Interleukin-1Β Antibodies Reduce Ischemia-Related Interleukin-1Β Transport Across The Blood-Brain Barrier In Fetal Sheep, Aparna Patra, Xiaodi Chen, Grazyna B. Sadowska, Jiyong Zhang, Yow-Pin Lim, James F. Padbury, William A. Banks, Barbara S. Stonestreet
Pediatrics Faculty Publications
Hypoxic ischemic insults predispose to perinatal brain injury. Pro-inflammatory cytokines are important in the evolution of this injury. Interleukin-1β (IL-1β) is a key mediator of inflammatory responses and elevated IL-1β levels in brain correlate with adverse neurodevelopmental outcomes after brain injury. Impaired blood-brain barrier (BBB) function represents an important component of hypoxic-ischemic brain injury in the fetus. In addition, ischemia-reperfusion increases cytokine transport across the BBB of the ovine fetus. Reducing pro-inflammatory cytokine entry into brain could represent a novel approach to attenuate ischemia-related brain injury. We hypothesized that infusions of neutralizing IL-1β monoclonal antibody (mAb) reduce IL-1β transport across …