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Full-Text Articles in Life Sciences
Synthesis And Characterization Of Tripodal-Imidazolium And Pyridazine Ruthenium Complexes And Their Associated Ligands, Jacqueline L. Kowalke
Synthesis And Characterization Of Tripodal-Imidazolium And Pyridazine Ruthenium Complexes And Their Associated Ligands, Jacqueline L. Kowalke
Lewis Honors College Capstone Collection
Photochemical therapy (PCT) is a relatively new treatment for cancer. PCT, unlike photodynamic therapy (PDT), does not require oxygen though it may be one of the mechanisms that the photosensitizer uses to destroy cancerous cells. Ruthenium complexes have recently entered clinical trials for the treatment of cancer. TLD1433, a ruthenium coordination complex, has entered phase II clinical trials for the treatment of non-muscular invasive bladder cancer. In this compound, the ligands are coordinated via nitrogen bonds, but in this paper, carbon-coordinated complexes are explored. Coordination of N-heterocyclic carbene (NHC) ligands to ruthenium is suspected to provide a different type of …
Role Of Satellite Cells In Long Term Fiber Type Shifts, Honglu Liu
Role Of Satellite Cells In Long Term Fiber Type Shifts, Honglu Liu
Lewis Honors College Capstone Collection
Muscle fiber type shifts in respect to satellite cells, muscle stem cells, are not well understood currently. The Peterson Lab has generated a mouse model (PAX7-DTA) that ablates satellite cells to determine if these muscle stem cells contribute to mouse muscle fiber type changes over an eight week period. In the study, control and satellite-cell-ablated mouse groups were split into control and overload groups (via synergist ablation surgery) and placed under similar environmental conditions. Eight weeks post-experiment, muscles were dissected to obtain the plantaris muscles of animals from all groups. Muscle cross-sections obtained were immunohistochemically stained, imaged, quantified by fiber …