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Anatomical And Behavioral Investigation Of C1ql3 In The Mouse Suprachiasmatic Nucleus, David C. Martinelli
Anatomical And Behavioral Investigation Of C1ql3 In The Mouse Suprachiasmatic Nucleus, David C. Martinelli
UCHC Articles - Research
Many biochemical, physiological, and behavioral processes such as glucose metabolism, body temperature, and sleep-wake cycles show regular daily rhythms. These circadian rhythms are adjusted to the environmental light-dark cycle by a central pacemaker located in the suprachiasmatic nucleus (SCN) in order for the processes to occur at appropriate times of day. Here, we investigated the expression and function of a synaptic organizing protein, C1QL3, in the SCN. We found that C1ql3 is robustly expressed in the SCN. C1ql3 knockout mice have a reduced density of excitatory synapses in the SCN. In addition, these mice exhibited less consolidated activity to the …