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Full-Text Articles in Life Sciences
Maternal Transmission Of Resistance To Development Of Allergic Airway Disease, Adam P. Matson, Li Zhu, Elizabeth G. Lingenheld, Craig M. Schramm, Robert B. Clark, Dawn M. Selander, Roger S. Thrall, Elena Breen, Lynn Puddington
Maternal Transmission Of Resistance To Development Of Allergic Airway Disease, Adam P. Matson, Li Zhu, Elizabeth G. Lingenheld, Craig M. Schramm, Robert B. Clark, Dawn M. Selander, Roger S. Thrall, Elena Breen, Lynn Puddington
UCHC Articles - Research
Parental phenotype is known to influence the inheritance of atopic diseases, such as allergic asthma, with a maternal history being a more significant risk factor for progeny than paternal history. We hypothesized that recall Th1- or Th2-type immune responses during pregnancy would result in transfer of maternal factors that would differentially impact development of immune responsiveness in offspring. Following weaning, susceptibility and severity of allergic airway disease (a murine model of human asthma) was evaluated in progeny, disease being elicited by immunization with OVA-Al(OH)3 and challenge with aerosolized OVA. We found that progeny of mothers with Th1-biased immunity to …