Life Sciences Commons^™

Pre-Training Muscle Characteristics Of Subjects Who Are Obese Determine How Well Exercise Training Will Improve Their Insulin Responsiveness, Charles A. Stuart, Michelle L. Lee, Mark A. South, Mary E. A. Howell, Brian M. Cartwright, Michael W. Ramsey, Michael H. Stone

Mark A. South

Pre-training muscle characteristics of subjects who are obese determine how well exercise training will improve their insulin responsiveness. J Strength Cond Res 31(3): 798–808, 2017—Only half of prediabetic subjects who are obese who underwent exercise training without weight loss increased their insulin responsiveness. We hypothesized that those who improved their insulin responsiveness might have pretraining characteristics favoring a positive response to exercise training. Thirty nondiabetic subjects who were obese volunteered for 8 weeks of either strength training or endurance training. During training, subjects increased their caloric intake to prevent weight loss. Insulin responsiveness by euglycemic clamps and muscle fiber composition, …

Pnaktide Attenuates Steatohepatitis And Atherosclerosis By Blocking Na/K-Atpase/Ros Amplification In C57bi6 And Apoe Knockout Mice Fed A Western Diet, K Sodhi, K Srikanthan, P Goguet-Rubio, A Nichols, A Mallick, A Nawab, R Martin, P Shah, M Chaudhry, S Sigdel, M El-Hamdani, J Liu, Z Xie, Nader Abraham, J Shapiro

Nader G. Abraham

We have previously reported that the alpha1 subunit of sodium potassium adenosine triphosphatase (Na/K-ATPase), acts as a receptor and an amplifier for reactive oxygen species, in addition to its distinct pumping function. On this background, we speculated that blockade of Na/K-ATPase-induced ROS amplification with a specific peptide, pNaKtide, might attenuate the development of steatohepatitis. To test this hypothesis, pNaKtide was administered to a murine model of NASH: the C57Bl6 mouse fed a "western" diet containing high amounts of fat and fructose. The administration of pNaKtide reduced obesity as well as hepatic steatosis, inflammation and fibrosis. Of interest, we also noted …

Pre-Training Muscle Characteristics Of Subjects Who Are Obese Determine How Well Exercise Training Will Improve Their Insulin Responsiveness, Charles A. Stuart, Michelle L. Lee, Mark A. South, Mary E. A. Howell, Brian M. Cartwright, Michael W. Ramsey, Michael H. Stone

Michael W. Ramsey

Pre-training muscle characteristics of subjects who are obese determine how well exercise training will improve their insulin responsiveness. J Strength Cond Res 31(3): 798–808, 2017—Only half of prediabetic subjects who are obese who underwent exercise training without weight loss increased their insulin responsiveness. We hypothesized that those who improved their insulin responsiveness might have pretraining characteristics favoring a positive response to exercise training. Thirty nondiabetic subjects who were obese volunteered for 8 weeks of either strength training or endurance training. During training, subjects increased their caloric intake to prevent weight loss. Insulin responsiveness by euglycemic clamps and muscle fiber composition, …

Vitamin D Status And Demographic And Lifestyle Determinants Among Adults In The United States (Nhanes 2001-2006), Yan Cao, Katie L. Callahan, Sreenivas P. Veeranki, Yang Chen, Ying Liu, Shimin Zheng

Shimin Zheng

This study looked at risk factors associated with vitamin D levels in the body among a representative sample of adults in the U.S., NHANES III (2001-2006) data were used to assess the relationship between several demographic and health risk factors and vitamin D levels in the body. The Baseline-Category Logit Model was used to test the association between vitamin D level and the potential risk factors age, education, ethnicity, poverty status, physical activity, smoking, alcohol, obesity, diabetes and total cholesterol with both genders. Vitamin D insufficiency and deficiency were significantly associated with age, race, education, physical activity, obesity, diabetes and …

Early Infant Feeding And Adiposity Risk: From Infancy To Adulthood, W H. Oddy, T A. Mori, R C Huang, J A. Marsh, C E. Pennell, Paola Chivers, Beth Hands, P Jacoby, P Rzehak, B V. Koletzko, L J. Beilin

Beth Hands

Introduction: Systematic reviews suggest that a longer duration of breast-feeding is associated with a reduction in the risk of later overweight and obesity. Most studies examining breast-feeding in relation to adiposity have not used longitudinal analysis. In our study, we aimed to examine early infant feeding and adiposity risk in a longitudinal cohort from birth to young adulthood using new as well as published data. Methods: Data from the Western Australian Pregnancy Cohort (Raine) Study in Perth, W.A., Australia, were used to examine associations between breast-feeding and measures of adiposity at 1, 2, 3, 6, 8, 10, 14, 17, and …

Early Infant Feeding And Adiposity Risk: From Infancy To Adulthood, W H. Oddy, T A. Mori, R C Huang, J A. Marsh, C E. Pennell, Paola Chivers, Beth Hands, P Jacoby, P Rzehak, B V. Koletzko, L J. Beilin

Paola Chivers

Introduction: Systematic reviews suggest that a longer duration of breast-feeding is associated with a reduction in the risk of later overweight and obesity. Most studies examining breast-feeding in relation to adiposity have not used longitudinal analysis. In our study, we aimed to examine early infant feeding and adiposity risk in a longitudinal cohort from birth to young adulthood using new as well as published data.

Methods: Data from the Western Australian Pregnancy Cohort (Raine) Study in Perth, W.A., Australia, were used to examine associations between breast-feeding and measures of adiposity at 1, 2, 3, 6, 8, 10, 14, 17, and …

Current Dietetic Practices Of Obesity Management In Saudi Arabia And Comparison With Australian Practices And Best Practice Criteria, A. Almajwal, P. Williams, Marijka Batterham

Dr Marijka Batterham

Objective: To describe the dietetic practices of the treatment of obesity in Saudi Arabia and compare this with best practice criteria and the practice in Australia. Methods: Anonymous questionnaires were completed by dietitians in Saudi Arabia. The topics included barriers to obesity management, demand and level of service and strategies and approaches used for weight management. Best practice scores were based on those used to assess Australian dietitians. Results: 253 dietitians participated in the survey. Of these, 175 (69 %) were involved in the management of obesity. The best practice score for Australian dietitians was slightly but significantly greater than …

Health Professionals’ Roles In Animal Agriculture, Climate Change, And Human Health, Aysha Z. Akhtar, Michael Greger, Hope Ferdowsian, Erica Frank

Michael Greger, MD, FACLM

What we eat is rapidly becoming an issue of global concern. With food shortages, the rise in chronic disease, and global warming, the impact of our dietary choices seems more relevant today than ever. Globally, a transition is taking place toward greater consumption of foods of animal origin, in lieu of plantbased diets. With this transition comes intensification of animal agriculture that in turn is associated with the emergence of zoonotic infectious diseases, environmental degradation, and the epidemics of chronic disease and obesity. Health professionals should be aware of these trends and consider them as they promote healthier and more …

History Of Fructose Use In Food Products, Jody L. Vogelzang Phd, Rdn, Fand, Ches

Jody L Vogelzang PhD, RDN, FAND, CHES

Food can be classified in ways other than by the nutrients they contain. In today’s fast moving culture, foods are characterized as having “magical” qualities that can turn consumers “superstars”, or reduce them to a less than optimal state of health and wellness. Sugars appear to be one of those vulnerable foodstuffs that can be enjoyed in moderation, but also contribute to the development of Type 2 Diabetes, metabolic syndrome, impaired cognitive function, obesity, and tooth decay .

Preventing Paediatric Obesity; Recommendations From A Community-Based Qualitative Investigation, Patricia Tucker, Jennifer Irwin, L. Sangster Bouck, Meizi He, G. Pollett

Trish Tucker

Childhood obesity is on the rise, and interventions targeted at pre-school-aged children are essential for the primary prevention of this disease. Physical activity programming and decreasing screen viewing may be advantageous ways to reduce the early onset of obesity. Parents' perceptions regarding effective tools and programmes to target obesity are needed to develop an efficacious programme. Ten semi-structured focus groups were conducted for this qualitative study. Two experienced moderators facilitated all focus groups which were conducted in local day cares, workplaces and play groups, frequented by parents. All focus groups were audio-recorded and transcribed verbatim. Strategies to ensure trustworthiness of …

Co-Active Coaching As An Intervention For Obesity Among Female University Students, Melissa Van Zandvoort, Jennifer Irwin, Don Morrow

Donald Morrow

Purpose: The purpose of this study was to assess the impact of Co-active coaching on obese female university students’ body mass index (BMI), waist circumference (WC), functional health status and self-esteem, and conjointly to identify the coaching skills and primary agenda topics that facilitate coaching’s efficacy as an intervention for obesity.

Design: A multiple-baseline, single-subject research design was utilized.Methods: Two certified coaches provided an average of nine, 35-minute, one-on-one sessions with five students whose BMI?30kg/m2 (obesity threshold). Measures included BMI, WC, the Short-Form 36 (SF-36) Health Survey, and the Rosenberg Self-Esteem Scale. Visual inspection was used to analyze changes in …

The Impact Of Co-Active Life Coaching On Female University Students With Obesity, Melissa Van Zandvoort, Jennifer Irwin, Don Morrow

Donald Morrow

The purpose of this qualitative study was to explore the impact of Co-active life coaching on obese female university students. Five obese (BMI ≥ 30kg/m2), female university students received an average of nine weekly, 35-minute, one-on-one sessions with a certified coach. Semi- structured, in-depth interviews before and after participating in the coaching intervention were conducted, and inductive content analysis was utilized. Strategies to enhance data trustworthiness were incorporated throughout. Participants initially reported: struggling with barriers and experiencing pressure from family to lose weight; negative relationships with themselves; feeling self-conscious and remorse for their size and lifestyle choices. At the conclusion …

Participants' Perceived Utility Of Motivational Interviewing Using Co-Active Life Coaching Skills On Their Struggle With Obesity, Courtney Newnham-Kanas, Don Morrow, Jennifer Irwin

Donald Morrow

The purpose of this qualitative study was to investigate the impact of Motivational Interviewing (MI) using Co-Active Life Coaching skills as a treatment for adults (age, 35–55 years) struggling with obesity. Eight women (BMI≥30) who reside in London, Ontario, received 18 coaching sessions over six months with a Certified Professional Co-Active (CPCC) coach. Participants engaged in semi-structured pre- and post-interviews, along with a focus group six months after the last coaching session. The study's CPCC was also interviewed post-intervention to gain an understanding of what it was like coaching this population. All interviews were analysed using inductive content analysis. Following …

The Quantitative Assessment Of Motivational Interviewing Using Co-Active Life Coaching Skills As A Treatment For Adults Struggling With Obesity, Courtney Newnham-Kanas, Jennifer Irwin, Don Morrow, Danielle Battram

Donald Morrow

No abstract provided.

Histamine H1 Receptor Agonist And Control Of Olanzapine-Induced Obesity, Jiamei Lian, Xu-Feng Huang, N Pai, C Deng

Xu-Feng Huang

No abstract provided.

Ventromedial Hypothalamic Npy Y2 Receptor In The Maintenance Of Body Weight In Diet-Induced Obesity In Mice, Yulin Li, Xu-Feng Huang, Chao Deng, Qing Wang, Timothy South, Yinghua Yu

Xu-Feng Huang

This study examined changes in neuropeptide Y (NPY) Y2 receptor binding in the brains of C57BL/6 mice in response to different levels of high-fat diets via three dietary intervention methods: high-fat diet, switching from high- to low-fat diet and finally, energy restricted high-fat diet. Forty-five C57Bl/6 male mice were fed a high-fat diet for 8 weeks and then classified as diet-induced obese (DIO) or diet-resistant (DR) mice according to the highest and lowest body weight gainers, respectively. The DIO and DR mice were then randomly divided into three groups each and either continued on their high-fat diet ad libitum (DIO-H …

A Link Between Chronic Sleep Restriction And Obesity: Methodological Considerations, Christopher Magee, Donald Iverson, Xu-Feng Huang, Peter Caputi

Xu-Feng Huang

Emerging evidence suggests that chronicsleeprestriction contributes to obesity. Targeting short sleep duration may therefore offer a novel and effective method of preventing and treating obesity. However, this area of research is only in its infancy, and a complete understanding of how chronicsleeprestriction and obesity are linked is currently lacking. The aim of this paper is to briefly review epidemiological evidence for an association between chronicsleeprestriction and obesity in adults, and outline the key methodological limitations of these studies. Particular attention is paid to the methods used to measure sleep and obesity, as well as the need to control for potential …

Effects Of Diets High In Whey, Soy, Red Meat And Milk Protein On Body Weight Maintenance In Diet-Induced Obesity In Mice, Xu-Feng Huang, Y Liu, Gita Rahardjo, Peter Mclennan, Linda Tapsell, William Buttemer

Xu-Feng Huang

This study examined the effects of different food sources of protein on energy intake, body weight maintenance, and on the responses of plasma leptin, insulin and adiponectin in chronic high-fat diet-induced obese mice. Obesity was induced in 47 mice with a high-fat diet for 20 weeks. They were divided into five diet groups to test the effects of a higher protein proportion (30% energy), achieved at the expense of carbohydrate. For the next eight weeks, four of the groups were fed diets of chow formulated with whey, soy, red meat or milk while the control group continued on their high-fat …

Examining The Pathways Linking Chronic Sleep Restriction To Obesity, Christopher A. Magee, Xu-Feng Huang, Donald C. Iverson, Peter Caputi

Xu-Feng Huang

A growing number of studies have identified chronic sleep restriction as a potential risk factor for obesity. This could have important implications for how obesity is prevented and managed, but current understanding of the processes linking chronic sleep restriction to obesity is incomplete. In this paper, we examined some of the pathways that could underlie the relationship between chronic sleep restriction and obesity. This involved exploring some of the potential environmental, health, behavioral, and sociodemographic determinants of chronic sleep restriction, which require further investigation in this context. Three pathways that could potentially link chronic sleep restriction to obesity were then …

Temporal And Site-Specific Brain Alterations In Cb1 Receptor Binding In High Fat Diet-Induced Obesity In C57bl/6 Mice, Xu-Feng Huang, Timothy South

Xu-Feng Huang

The cannabinoid CB1 receptor has been implicated in the regulation of appetite and the consumption of palatable foods. This experiment aimed to explore the involvement of the CB1 receptor in the early and late stages of high fat diet-induced obesity in C57BL/6 mice. The C57Bl/6 mice were placed on a high fat (HF) or low fat/high carbohydrate (LF) diet for 3 or 20 weeks. Quantitative autoradiography revealed that binding of [3H] CP-55,940 (CB1 receptor ligand) was elevated following 3 weeks of HF feeding in areas including the medial/ventral anterior olfactory nucleus (22.1%), agranular insular cortex (24.0%) and the hypothalamus (31.5%) …

G Protein-Coupled Receptor 12 Deficiency Results In Decreased Energy Expenditure, Dyslipidemia And Obesity In Mice, L. Svensson, Xu-Feng Huang, M Jonnson, M Bjursell, M Boholooly, J Tornell, V Surve, A Gerdin

Xu-Feng Huang

No abstract provided.

Differential Expression Of Dopamine D2 And D4 Receptor And Tyrosine Hydroxylase Mrna In Mice Prone, Or Resistant, To Chronic High-Fat Diet-Induced Obesity, Xu-Feng Huang, Yinghua Yu, Katerina Zavitsanou, Mei Han, Leonard Storlien

Xu-Feng Huang

The present study examined brain dopamine D2 and D4 receptor and tyrosine hydroxylase (TH) mRNA expression in chronic high-fat diet-induced obese (cDIO) and obese-resistant (cDR) mice. Twenty-eight mice were fed a high-fat diet (HF: 40% of calories from fat) for 6 weeks and then classified as cDIO (n = 8) or cDR (n = 8) mice according to the highest and lowest body weight gainers, respectively. Seven mice were fed a low-fat diet (LF: 10% of calories from fat) and used as controls. After 20 weeks of feeding, visceral fat per gram of initial body weight was significantly higher in …

Diets High In Oat-Derived Beta-Glucan Promote Negative Energy Regulatory Pathway Of Hypothalamic Npy System In Chronic Diet-Induced Obesity In Mice, Xu-Feng Huang, Timothy South, Eleanor Beck, Marijka Batterham, K. Grinter, Linda Tapsell

Xu-Feng Huang

No abstract provided.

Dopamine Transporter And D2 Receptor Densities In Mice Prone Or Resistant To Chronic High-Fat Diet-Induced Obesity, Xu-Feng Huang, F Chen, A Lawrence, Katerina Zavitsanou, Chao Deng, Hong-Qin Wang, Yinghua Yu

Xu-Feng Huang

No abstract provided.

Medical And Surgical Treatment Of Obesity, Timothy C. Beer

Timothy C Beer

A brief overview of the most common FDA approved medications and surgical procedures used to treat obesity.

Fat In Food And The Obesity Epidemic, Linda C. Tapsell

L. C. Tapsell

Dietary fat is strongly implicated in the development of insulin resistance and obesity, both major public health problems today. While the amount of dietary fat is relevant, the type of fat is important in fuel utilisation, storage and appetite regulatory mechanisms. Human calorimetry research confirms the importance of dietary fat in energy balance, but more work needs to be done to uncover the impact of type of dietary fat in weight control. Population and intervention research confirm the importance of fat in dietary interventions, bearing in mind the contribution of physical activity to energy balance. The food industry has an …

Is Sleep Duration Associated With Obesity In Older Australian Adults?, Christopher A. Magee, Peter Caputi, Don C. Iverson

Don C. Iverson

Objectives: To investigate the relationship between sleep duration and obesity in older Australian adults. Method: Self-reported health data were collected through the 45 and Up Study. Multinomial logistic regression models were used to test the relationship between sleep duration and body mass index, controlling for a range of demographic and health-related variables. Results: The sample included 45,325 Australian adults aged 55 to 95 years. The regression models demonstrated that short and long sleep were associated with obesity in 55- to 64-year-olds but not in those aged 65 years and above. Discussion: The present results suggest that the relationships between sleep …

A Link Between Chronic Sleep Restriction And Obesity: Methodological Considerations, Christopher Magee, Donald Iverson, Xu-Feng Huang, Peter Caputi

Don C. Iverson

Emerging evidence suggests that chronicsleeprestriction contributes to obesity. Targeting short sleep duration may therefore offer a novel and effective method of preventing and treating obesity. However, this area of research is only in its infancy, and a complete understanding of how chronicsleeprestriction and obesity are linked is currently lacking. The aim of this paper is to briefly review epidemiological evidence for an association between chronicsleeprestriction and obesity in adults, and outline the key methodological limitations of these studies. Particular attention is paid to the methods used to measure sleep and obesity, as well as the need to control for potential …

Sleep Duration And Obesity In Middle-Aged Australian Adults, Christopher A. Magee, Donald C. Iverson, Peter Caputi

Don C. Iverson

The present study examined the association between sleep duration and obesity in 40,834 middle-aged Australian adults. Multinomial logistic regression was used to test the relationship between sleep duration and obesity while controlling for important demographic and health covariates; separate models were tested for males and females. Short sleep (i.e., <7 h a night) was found to be independently associated with obesity in males and females. To our knowledge, this is the first study to report an association between short sleep and obesity in Australian adults. Although more research is required, interventions targeting short sleep could aid obesity treatment and prevention.

Family Practice Residents' Identification And Management Of Obesity, R Mcartor, Donald Iverson, D Benken, L Dennis

Don C. Iverson

This study, involving 25 family practice residents and 2746 patients in a family practice residency programme, addressed four hypotheses regarding the identification and management of obesity in the primary care setting: (i) the physician-identified prevalence of obesity is significantly lower than the actual prevalence in the population, (ii) obesity is more likely to be addressed with management actions when it is recorded on the medical record problem list than when it is not recorded, (iii) physician actions dealing with obesity are influenced by the patient's age, sex, level of motivation, and body mass index (BMI) value, and (iv) the type …