Open Access. Powered by Scholars. Published by Universities.®
- File Type
Articles 1 - 3 of 3
Full-Text Articles in Life Sciences
A Cytoplasmic Rna Virus Generates Functional Viral Small Rnas And Regulates Viral Ires Activity In Mammalian Cells, Kuo-Feng Weng, Chuan-Tien Hung, Po-Ting Hsieh, Mei-Ling L. Li, Guang-Wu Chen, Yu-An Kung, Peng-Nien Huang, Rei-Lin Kuo, Li-Lien Chen, Jing-Yi Lin, Robert Yung-Liang Wang, Shu-Jen Chen, Petrus Tang, Jim-Tong Horng, Hsing-I Huang, Jen-Ren Wang, David M. Ojcius, Gary Brewer, Shin-Ru Shih
A Cytoplasmic Rna Virus Generates Functional Viral Small Rnas And Regulates Viral Ires Activity In Mammalian Cells, Kuo-Feng Weng, Chuan-Tien Hung, Po-Ting Hsieh, Mei-Ling L. Li, Guang-Wu Chen, Yu-An Kung, Peng-Nien Huang, Rei-Lin Kuo, Li-Lien Chen, Jing-Yi Lin, Robert Yung-Liang Wang, Shu-Jen Chen, Petrus Tang, Jim-Tong Horng, Hsing-I Huang, Jen-Ren Wang, David M. Ojcius, Gary Brewer, Shin-Ru Shih
David M. Ojcius
The roles of virus-derived small RNAs (vsRNAs) have been studied in plants and insects. However, the generation and function of small RNAs from cytoplasmic RNA viruses in mammalian cells remain unexplored. This study describes four vsRNAs that were detected in enterovirus 71-infected cells using next-generation sequencing and northern blots. Viral infection produced substantial levels (>105 copy numbers per cell) of vsRNA1, one of the four vsRNAs. We also demonstrated that Dicer is involved in vsRNA1 generation in infected cells. vsRNA1 overexpression inhibited viral translation and internal ribosomal entry site (IRES) activity in infected cells. Conversely, blocking vsRNA1 enhanced viral …
Dental Enamel As A Dietary Indicator In Mammals, Peter Lucas, Paul Constantino, Bernard Wood, Brian Lawn
Dental Enamel As A Dietary Indicator In Mammals, Peter Lucas, Paul Constantino, Bernard Wood, Brian Lawn
Paul J. Constantino
The considerable variation in shape, size, structure and properties of the enamel cap covering mammalian teeth is a topic of great evolutionary interest. No existing theories explain how such variations might be fit for the purpose of breaking food particles down. Borrowing from engineering materials science, we use principles of fracture and deformation of solids to provide a quantitative account ofhowmammalian enamelmay be adapted to diet. Particular attention is paid to mammals that feed on ‘hard objects’ such as seeds and dry fruits, the outer casings of which appear to have evolved structures with properties similar to those of enamel. …
In Vitro And In Vivo Models Of Acute Alcohol Exposure, Angela Dolganiuc, Gyongyi Szabo
In Vitro And In Vivo Models Of Acute Alcohol Exposure, Angela Dolganiuc, Gyongyi Szabo
Gyongyi Szabo
Alcohol abuse is a global problem due to the financial burden on society and the healthcare system. While the harmful health effects of chronic alcohol abuse are well established, more recent data suggest that acute alcohol consumption also affects human wellbeing. Thus, there is a need for research models in order to fully understand the effect of acute alcohol abuse on different body systems and organs. The present manuscript summarizes the interdisciplinary advantages and disadvantages of currently available human and non-human models of acute alcohol abuse, and identifies their suitability for biomedical research.