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Medicine and Health Sciences

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Antimicrobial

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The New Penicillin?, Nikki Huynh Apr 2017

The New Penicillin?, Nikki Huynh

Nikki Huynh

Clostridium difficile infects and kills 30,000-40,000 people a year in the United States. In order to target and minimize the spread of C. difficile we are screening puupehenone, a natural marine product that is excreted from some species of sponges and coral as a defense mechanism, and repurposing its role for medical use. Our research primarily focuses on determining puupehenone’s antimicrobial properties. This was determined by testing the minimum inhibitory concentration (MIC) of puupehenone as it relates to a single strain of C. difficile, and then observing whether the antimicrobial properties hold across multiple strains of the bacterium. The strain …

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Phytochemical Analysis And Biological Activities Of Cola Nitida Bark, Durand Dah-Nouvlessounon, Mamoudou H. Dicko Prof., Lamine Baba-Moussa Jan 2015

Phytochemical Analysis And Biological Activities Of Cola Nitida Bark, Durand Dah-Nouvlessounon, Mamoudou H. Dicko Prof., Lamine Baba-Moussa

Pr. Mamoudou H. DICKO, PhD

The aim of this study is to investigate some biological effects of Cola nitida’s bark after phytochemical screening. The bark was collected, dried, and then powdered for the phytochemical screening and extractions. Ethanol and ethyl acetate extracts of C. nitida were used in this study. The antibacterial activity was tested on ten reference strains and 28 meat isolated Staphylococcus strains by disc diffusionmethod. The antifungal activity of three fungal strains was determined on the Potato-Dextrose Agar medium mixed with the appropriate extract. The antioxidant activity was determined by DPPH and ABTS methods. Our data revealed the presence of various potent …

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