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Role Of Ampa And Glur5 Kainate Receptors In The Development And Expression Of Amygdala Kindling In The Mouse, Michael A. Rogawski, Philip S. Kurzman, Shun-Ichi Yamaguchi, He Li
Role Of Ampa And Glur5 Kainate Receptors In The Development And Expression Of Amygdala Kindling In The Mouse, Michael A. Rogawski, Philip S. Kurzman, Shun-Ichi Yamaguchi, He Li
Michael A. Rogawski
The role of AMPA and GluR5-containing kainate receptors in the development and expression of amygdala kindling was examined using the selective 2,3-benzodiazepine AMPA receptor antagonist GYKI 52466 [(1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2, 3-benzodiazepine] and the decahydroisoquinoline mixed AMPA receptor and GluR5 kainate receptor antagonist LY293558 {(3S,4aR,6R, 8aR)-6-[2-(1(2)H-tetrazole-5-yl)ethyl]decahydroisoquinoline- 3-carboxy lic acid)}. Administration of GYKI 52466 (5-40 mg/kg, intraperitoneally) and LY293558 (10-40 mg/kg, intraperitoneally) prior to daily kindling stimulation in mice produced a dose-dependent suppression of the rate of development of behavioral kindled seizure activity and reduced the duration of the stimulation-induced electrographic afterdischarge. In drug-free stimulation sessions after the initial drug-treatment sessions, there was an …