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A Single High‐Fat Meal Alters Human Soluble Rage Profiles And Pbmc Rage Expression With No Effect Of Prior Aerobic Exercise, Kelly N.Z. Fuller, Rudy J. Valentine, Edwin R. Miranda, Prabhakaran Kumar, Bellur S. Prabhakar, Jacob M. Haus
A Single High‐Fat Meal Alters Human Soluble Rage Profiles And Pbmc Rage Expression With No Effect Of Prior Aerobic Exercise, Kelly N.Z. Fuller, Rudy J. Valentine, Edwin R. Miranda, Prabhakaran Kumar, Bellur S. Prabhakar, Jacob M. Haus
Rudy Valentine
A high‐fat diet can induce inflammation and metabolic diseases such as diabetes and atherosclerosis. The receptor for advanced glycation endproducts (RAGE) plays a critical role in metabolic disease pathophysiology and the soluble form of the receptor (sRAGE) can mitigate these effects. However, little is known about RAGE in the postprandial condition and the effect of exercise in this context. Thus, we aimed to determine the effects of a single high‐fat meal (HFM) with and without prior exercise on peripheral blood mononuclear cell (PBMC) RAGE biology. Healthy males (n = 12) consumed a HFM on two occasions, one without prior …