Life Sciences Commons^™

Theoretical Framework For The Study Of Genetic Diseases Caused By Dominant Alleles, Michael Roberts, Stephen Bricher

Articles, Essays, & Creative Writing

We propose a theoretical basis for analyzing several features of genetic diseases caused by dominant alleles, including: disease prevalence, genotype penetrance, and the relationship between causal genotype frequency and disease frequency. In addition, we provide a theoretical framework for accurate diagnosis and clinical approaches for disease study, including two examples in which inaccurate and incomplete diagnoses affect the estimates of disease prevalence: First, the disease iceberg effect shows that disease prevalence is often underestimated due to errors introduced by inaccurate diagnosis; second, because lifetime risk of disease is cumulative, and therefore an increasing function of age, measurements of prevalence are …

Investigating The Redox Sensitivity Of Mitf Splice Variants, Rachel Berryman

Senior Theses

Within pigment-producing cells known as melanocytes, the transcription factor MITF is intimately involved in regulating genes associated with cell cycle maintenance and melanocyte differentiation. Research, however, has provided conflicting results on the relationship between the expression levels of MITF and melanocyte cell fate. To complicate matters, two splice variants of MITF exist, differing by only 18 base pairs. These variants have been observed at variable levels of expression in melanocyte and melanoma cells, raising the question as to their functional purpose. Building upon previous research by the Leachman/Cassidy lab that identified the redox sensitivity of MITF while additionally establishing a …

Yeast Copper Proteins And Reactive Oxygen Species In Effecting Lifespan, Megan Bestwick

Post-Grant Reports

Mitochondria are essential organelles in most eukaryotic cells because of their role in metabolism and the production of ATP by the oxidative phosphorylation (OXPHOS) pathway, as well as other key cellular processes. Metal cofactors, such as copper (Cu) and iron (Fe), are incorporated into OXPHOS protein complexes of yeast located within the inner membrane of the mitochondria. Misincorporation or modulation of these available metals in mitochondrial enzymes leads to the production of reactive oxygen species (ROS). ROS are reactive molecules containing oxygen such as peroxides, superoxide, and hydroxyl radicals. Yeast are a good model for studying aging and the effect …

Student-Faculty Collaborative Research Grant Report, Megan Bestwick

Post-Grant Reports

Mitochondria are essential organelles in most eukaryotic cells because of their role in metabolism and the production of ATP by the oxidative phosphorylation (OXPHOS) pathway, as well as other key cellular processes. Metal cofactors, such as copper (Cu) and iron (Fe), are incorporated into OXPHOS protein complexes of yeast located within the inner membrane of the mitochondria. Misincorporation or modulation of these available metals in mitochondrial enzymes leads to the production of reactive oxygen species (ROS). ROS are reactive molecules containing oxygen such as peroxides, superoxide, and hydroxyl radicals. Yeast are a good model for studying aging and the effect …

In Place: May 25, 2018, Place

PLACE Historical Documents

In PLACE is a newsletter designed to keep the Linfield College community apprised of information related to PLACE activities, as well as ways to bring the program into classes. Included in this issue:

• Spotlight On: PLACE's Upcoming Theme, Revolutions
• Announcing: PLACE Fellows, 2018-2019
• Last Week in PLACE

In Place: April 16, 2018, Place

PLACE Historical Documents

In PLACE is a newsletter designed to keep the Linfield College community apprised of information related to PLACE activities, as well as ways to bring the program into classes. Included in this issue:

• Spotlight On: The Politicization of Science, P. II
• Upcoming Events
• PLACE in the News

In Place: March 12, 2018, Place

PLACE Historical Documents

In PLACE is a newsletter designed to keep the Linfield College community apprised of information related to PLACE activities, as well as ways to bring the program into classes. Included in this issue:

• Spotlight On: Leadership and the Liberal Arts Skills Development Series
• Upcoming Events
• The Last Weeks in PLACE

In Place: November 27, 2017, Place

PLACE Historical Documents

In PLACE is a newsletter designed to keep the Linfield College community apprised of information related to PLACE activities, as well as ways to bring the program into classes. Included in this issue:

• Spotlight On: "What's the Big Idea"
• Upcoming Events
• PLACE in the News

In Place: November 6, 2017, Place

PLACE Historical Documents

In PLACE is a newsletter designed to keep the Linfield College community apprised of information related to PLACE activities, as well as ways to bring the program into classes. Included in this issue:

• Spotlight On: PLACE Sponsored Events
• Upcoming Events
• PLACE in the News

In Place: October 11, 2017, Place

PLACE Historical Documents

In PLACE is a newsletter designed to keep the Linfield College community apprised of information related to PLACE activities, as well as ways to bring the program into classes. Included in this issue:

• A Message to Faculty
• Spotlight On: Jonathan Rauch & Cheryl Harris
• Upcoming Events
• PLACE in the News
• Last Week in PLACE

In Place: September 24, 2017, Place

PLACE Historical Documents

In PLACE is a newsletter designed to keep the Linfield College community apprised of information related to PLACE activities, as well as ways to bring the program into classes. Included in this issue:

• PLACE: What's In It for Faculty?
• PLACE: What's In It for Students?
• PLACE in the News
• Last Week in PLACE

In Place: September 8, 2017, Place

PLACE Historical Documents

In PLACE is a newsletter designed to keep the Linfield College community apprised of information related to PLACE activities, as well as ways to bring the program into classes. Included in this issue:

• PLACE and What's the Big Idea?
• Spotlight On: The First Year Experience
• Our PLACE Theme in the News

Student Fellows 2017-2018, Place

PLACE Historical Documents

This document provides biographies of PLACE student fellows at Linfield College for 2017-2018.

Faculty Fellows 2017-2018, Place

PLACE Historical Documents

This document provides biographies of PLACE faculty fellows at Linfield College for 2017-2018.

The Digital Citizen, Place

PLACE Historical Documents

This document explains the PLACE theme at Linfield College for 2017-2018 (The Digital Society: The Digital Citizen).

Examination Of The Monoamine Oxidase A Gene Promoter On Motivation To Exercise And Levels Of Voluntary Physical Activity, Erin M. Kinney

Senior Theses

Purpose: The purpose of this study was to examine the genetic basis underlying voluntary exercise. Monoamine oxidase A (MAO-A) is an enzyme that acts on monoamine neurotransmitters, such as dopamine, to cause inactivation. There are several polymorphisms in the promoter region of the MAO-A gene, and these variations change transcriptional activity and the amount of MAO-A produced, leading to alterations in available dopamine levels. Interestingly, polymorphisms in MAO-A have been associated recently with physical activity level. This study sought to determine whether there is an association between motivation to exercise, levels of voluntary physical activity, and MAO-A gene polymorphisms.

Methods: …

Place Events 2016-2017, Place

PLACE Historical Documents

This document describes PLACE events at Linfield College for 2016-2017.

The Digital Society, Place

PLACE Historical Documents

This document explains the PLACE theme at Linfield College for 2016-2018 (The Digital Society).

Place Events 2015-2016, Place

PLACE Historical Documents

This document describes PLACE events at Linfield College for 2015-2016.

Student Fellows 2015-2016, Place

PLACE Historical Documents

This document provides biographies of PLACE student fellows at Linfield College for 2015-2016.

Faculty Fellows 2015-2016, Place

PLACE Historical Documents

This document provides biographies of PLACE faculty fellows at Linfield College for 2015-2016.

Air, Water, Earth, And Fire: The Ancient Elements On A Changing Planet, Place

PLACE Historical Documents

This document explains the PLACE theme at Linfield College for 2015-2016 (Air, Water, Earth, and Fire: The Ancient Elements on a Changing Planet).

Place Events Spring 2015, Place

PLACE Historical Documents

This document describes PLACE events at Linfield College for spring 2015.

Place Events Fall 2014, Place

PLACE Historical Documents

This document describes PLACE events at Linfield College for fall 2014.

How Do We Know? Paths To Wisdom, Place

PLACE Historical Documents

This document explains the PLACE theme at Linfield College for 2014-2015 (How Do We Know? Paths to Wisdom).

Place Events Spring 2014, Place

PLACE Historical Documents

This document describes PLACE events at Linfield College for spring 2014.

Place Events Spring 2014 Highlights, Place

PLACE Historical Documents

This document summarizes highlights of PLACE events at Linfield College for spring 2014.

Faculty Fellows 2013-2014, Place

PLACE Historical Documents

This document provides biographies of PLACE faculty fellows at Linfield College for 2013-2014.

Place Related Courses 2013-2014, Place

PLACE Historical Documents

This document includes a complete list of all the related courses for the PLACE program at Linfield College from 2013-2014.

Student Fellows 2013-2014, Place

PLACE Historical Documents

This document provides biographies of PLACE student fellows at Linfield College for 2013-2014.