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Full-Text Articles in Life Sciences
Deep Sequencing Analyses Expands The Pseudomonas Aeruginosa Ampr Regulon To Include Small Rna-Mediated Regulation Of Iron Acquisition, Heat Shock And Oxidative Stress Response, Deepak Balasubramania, Hansi Kumari, Melita Jaric, Mitch Fernandez, Keith H. Turner, Simon L. Dove, Giri Narasimhan, Stephen Lory, Kalai Mathee
Deep Sequencing Analyses Expands The Pseudomonas Aeruginosa Ampr Regulon To Include Small Rna-Mediated Regulation Of Iron Acquisition, Heat Shock And Oxidative Stress Response, Deepak Balasubramania, Hansi Kumari, Melita Jaric, Mitch Fernandez, Keith H. Turner, Simon L. Dove, Giri Narasimhan, Stephen Lory, Kalai Mathee
Department of Biological Sciences
Pathogenicity of Pseudomonas aeruginosa, a major cause of many acute and chronic human infections, is determined by tightly regulated expression of multiple virulence factors. Quorum sensing (QS) controls expression of many of these pathogenic determinants. Previous microarray studies have shown that the AmpC β-lactamase regulator AmpR, a member of the LysR family of transcription factors, also controls non-β-lactam resistance and multiple virulence mechanisms. Using RNA-Seq and complementary assays, this study further expands the AmpR regulon to include diverse processes such as oxidative stress, heat shock and iron uptake. Importantly, AmpR affects many of these phenotypes, in part, by regulating expression …
A K2a-Positive Klebsiella Pneumoniae Causes Liver And Brain Abscess In A Saint Kitt’S Man, Melissa S. Doud, Reni Grimes-Zeppegno, Enrique Molina, Nancimae Miller, Danajeyan Balachandar, Lisa Schneper, Robert Poppiti, Kalai Mathee
A K2a-Positive Klebsiella Pneumoniae Causes Liver And Brain Abscess In A Saint Kitt’S Man, Melissa S. Doud, Reni Grimes-Zeppegno, Enrique Molina, Nancimae Miller, Danajeyan Balachandar, Lisa Schneper, Robert Poppiti, Kalai Mathee
Department of Biological Sciences
Klebsiella pneumoniae isolated in community-acquired pneumonia is increasingly found in primary pyogenic liver abscesses. The presence of magA in K. pneumoniae has been implicated in hypermucoviscosity and virulence of liver abscess isolates. The K2 serotype has also been strongly associated with hypervirulence. We report the isolation of non-magA, K2 K. pneumoniae strain from a liver abscess of a Saint Kitt’s man who survived the invasive syndrome.