Life Sciences Commons^™

Cancer Immunoprevention And Public Health, Sandeep K. Singh, Mehmet Tevfik Dorak

All Faculty

The power of cancer immune surveillance has been documented beyond doubt, and the successful exploitation of immune response to cancer has started a new era in the war against cancer. Cancer biologists have recognized immunoevasion as an emerging hallmark in addition to the six hallmarks of cancer. Besides the natural connection between the immune system and cancer development, most established environmental risk factors are now known to interfere with immune surveillance mechanisms. Genetic variations regulating immunity may also modulate cancer susceptibility, but evidence for this is currently limited. Molecular cross talk linking ?immune? and ?genomic? surveillance pathways has been characterized. …