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Life Sciences Commons

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Medicine and Health Sciences

Claremont Colleges

CMC Senior Theses

Cognitive Decline

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Crispr-Cas9 Mediated Hmgcl Ko In 3xtg Ad Mice Reduces The Cognitive Deficit Improvement Seen In An Intermittent Metabolic Switching Regimen, Eric Joon Bum Kil Jan 2018

Crispr-Cas9 Mediated Hmgcl Ko In 3xtg Ad Mice Reduces The Cognitive Deficit Improvement Seen In An Intermittent Metabolic Switching Regimen, Eric Joon Bum Kil

CMC Senior Theses

Individuals in modern Western societies are experiencing increasing sedentary lifestyles, overindulgence of high fat, high-sugar diets, and extremely sterilized conditions, putting immense pressure on researchers and clinicians alike to come up with viable treatments for conditions implicated with an aging society. Emerging research have published the benefits of IMS and metabolic switching in a variety of neuroprotective, cellular stress resistance, and neuroplasticity pathways in animal models and clinical results from randomized trials of IMS regimens with susceptible human populations are soon to be published. The application of genome editing and next-generation sequencing (NGS) strategies to clinical and neurodegenerative research continues …