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Full-Text Articles in Life Sciences
Dietary Restriction Enhances Circadian Amplitude And Delays Visual Decline By A Clock-Driven Increase In Phototransduction, Geoff Meyerhof
Dietary Restriction Enhances Circadian Amplitude And Delays Visual Decline By A Clock-Driven Increase In Phototransduction, Geoff Meyerhof
Natural Sciences and Mathematics | Biological Sciences Master's Theses
Aging is accompanied by a progressive loss of circadian rhythms. Lifespan-extending dietary paradigms such as dietary restriction (DR) enhance circadian amplitude and appear to extend lifespan in a clock-dependent fashion. However, the mechanisms by which DR amplifies circadian rhythms and why circadian rhythms decline with age have yet to be fully elucidated. Here we find that DR amplifies circadian amplitude by enhancing light sensitivity in the eye. We performed a circadian mRNA microarray in flies (Drosophila melanogaster) reared on DR or a high nutrient diet and found that DR increases the number of circadian transcripts and selectively amplifies the …
Action Spectrum For Photoentrainment Of The Circadian Clock In Wild-Type Chlamydomonas Reinhardtii, Jennifer Forbes=Stovall
Action Spectrum For Photoentrainment Of The Circadian Clock In Wild-Type Chlamydomonas Reinhardtii, Jennifer Forbes=Stovall
Masters Theses & Specialist Projects
The circadian clock is an endogenous timer that oscillates with a period of approximately 24 hours and is reset upon environmental time cues such as the daily light/ dark or temperature cycles. Chlamydomonas reinhardtii is an ideal model organism for research on the circadian clock, because it shows several well-characterized behaviors that exhibit a circadian rhythm. Its circadian rhythm of phototaxis (swimming toward light) has been automated. Former action spectrum studies using the circadian phototaxis rhythm as an indicator surprisingly found that pulses of blue light were not effective in resetting the circadian clock of dark-adapted cells. This may have …