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The Branched Actin Nucleator Arp2/3 Promotes Nuclear Migrations And Cell Polarity In The C. Elegans Zygote, William A. Mohler
The Branched Actin Nucleator Arp2/3 Promotes Nuclear Migrations And Cell Polarity In The C. Elegans Zygote, William A. Mohler
UCHC Articles - Research
Regulated movements of the nucleus are essential during zygote formation, cell migrations, and differentiation of neurons. The nucleus moves along microtubules (MTs) and is repositioned on F-actin at the cellular cortex. Two families of nuclear envelope proteins, SUN and KASH, link the nucleus to the actin and MT cytoskeletons during nuclear movements. However, the role of actin nucleators in nuclear migration and positioning is poorly understood. We show that the branched actin nucleator, Arp2/3, affects nuclear movements throughout embryonic and larval development in C. elegans, including nuclear migrations in epidermal cells and neuronal precursors. In one-cell embryos the migration …