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Full-Text Articles in Life Sciences
Division Of Labor Between Subsets Of Lymph Node Dendritic Cells Determines The Specificity Of The Cd8 Recall Response To Influenza Infection, Jenny E. Suárez-Ramírez, Tao Wu, Young-Tae Lee, Carolina C. Aguila, Keith R. Bouchard, Linda Linda Cauley
Division Of Labor Between Subsets Of Lymph Node Dendritic Cells Determines The Specificity Of The Cd8 Recall Response To Influenza Infection, Jenny E. Suárez-Ramírez, Tao Wu, Young-Tae Lee, Carolina C. Aguila, Keith R. Bouchard, Linda Linda Cauley
UCHC Articles - Research
Cytotoxic T lymphocytes are important targets for vaccines against a wide variety of infections that enter the body via mucosal tissues. To induce effective immunity these vaccines must include the most protective epitopes and elicit rapid recall responses at the site of infection. Although live attenuated viruses are sometimes used to induce cellular immunity against recurrent influenza infections, the mechanisms that determine the magnitude of the response to individual viral components are very poorly defined. Heterosubtypic infections in B6 mice illustrate an additional level of complexity, when the antigen-specificity of the response shifts dramatically between primary and secondary challenge. This …