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Full-Text Articles in Life Sciences
Role Of Vascular Endothelial Growth Factor, Placental Growth Factor And Cytokines On Outer Blood Retinal Barrier Breakdown., Sangeetha Sukumaran
Role Of Vascular Endothelial Growth Factor, Placental Growth Factor And Cytokines On Outer Blood Retinal Barrier Breakdown., Sangeetha Sukumaran
Masters
The aim of this thesis was to investigate the effect of the VEGF family of growth factors and
cytokines TNF- α and IL-1β on oBRB function. The human RPE line ARPE-19 was
employed as an in vitro model of the oBRB. Two-Dimensional gel electrophoresis was
employed to study the effect of growth factors on the RPE proteome. The barrier properties of
the oBRB were evaluated by expression of the TJ proteins occludin or Zo-1, or claudins-1, 2,
3 and 4, determined by western blotting analysis. Claudins 2, 3 and 4 were found to be
significantly up-regulated by TNF-α, while interleukin …
Ecotoxicological Investigations Of Pharmaceutical Compounds On A Battery Of Freshwater Test Species., Elaine Minagh
Ecotoxicological Investigations Of Pharmaceutical Compounds On A Battery Of Freshwater Test Species., Elaine Minagh
Masters
Currently interest in pharmaceuticals as potential environmental contaminants has increases significantly. This is due to the awareness of the possible adverse effects to human health and the environment caused by such contaminants. Within the past few years, the highly prescribed antidepressants, selective serotonin reuptake inhibitors (SSRI), have received attention as their occurrence in the environment has been recently documented. Prior to this, there was very little known about the ecotoxicity of SSRIs, and in particular sertraline hydrochloride. Similarly the cholesterol-lowering drugs, known as statins are among the most frequently prescribed agents in Ireland and worldwide for the treatment of coronary …
An Investigation Of The Safety Of High Risk Sandwich Bar Foods Through The Application Of Microbial Analysis, Temperature Monitoring And Microbial Predictive Modelling, Marie-Clare Maher
An Investigation Of The Safety Of High Risk Sandwich Bar Foods Through The Application Of Microbial Analysis, Temperature Monitoring And Microbial Predictive Modelling, Marie-Clare Maher
Masters
Rising incidents of food poisoning may be related to growing evidence of unsatisfactory temperature and hygiene practices in preparing and storing ready-to-eat foods. Four sandwich bar outlets in Dublin city center were observed regarding the quality of food handling and storage practices of chilled vacuum packed cooked chicken breast. A pilot microbial sampling plan proved Staphylococcus aureus was the major microorganism of concern. Microbial counts revealed a S. aureus count of ) cfu/g on chicken straight form the vacuum pack and a count of 10(3)-10(4) cfu/g after handling/preparation (cutting, slicing and blending) had occurred. This compared poorly to the upper …