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Full-Text Articles in Life Sciences
Vectored Intracerebral Immunization With The Anti-Tau Monoclonal Antibody Phf1 Markedly Reduces Tau Pathology In Mutant Tau Transgenic Mice, Wencheng Liu, Lingzhi Zhao, Brittany Blackman, Mayur Parmar, Man Ying Wong, Thomas Woo, Fangmin Yu, Maria J. Chiuchiolo, Dolan Sondhi, Stephen M. Kaminsky, Ronald G. Crystal, Steven M. Paul
Vectored Intracerebral Immunization With The Anti-Tau Monoclonal Antibody Phf1 Markedly Reduces Tau Pathology In Mutant Tau Transgenic Mice, Wencheng Liu, Lingzhi Zhao, Brittany Blackman, Mayur Parmar, Man Ying Wong, Thomas Woo, Fangmin Yu, Maria J. Chiuchiolo, Dolan Sondhi, Stephen M. Kaminsky, Ronald G. Crystal, Steven M. Paul
HPD Articles
UNLABELLED: Passive immunization with anti-tau monoclonal antibodies has been shown by several laboratories to reduce age-dependent tau pathology and neurodegeneration in mutant tau transgenic mice. These studies have used repeated high weekly doses of various tau antibodies administered systemically for several months and have reported reduced tau pathology of ∼40-50% in various brain regions. Here we show that direct intrahippocampal administration of the adeno-associated virus (AAV)-vectored anti-phospho-tau antibody PHF1 to P301S tau transgenic mice results in high and durable antibody expression, primarily in neurons. Hippocampal antibody levels achieved after AAV delivery were ∼50-fold more than those reported following repeated systemic …
Human Anatomy & Physiology Society ( Haps ) Southern Regional Meeting 2016, Cheryl Purvis
Human Anatomy & Physiology Society ( Haps ) Southern Regional Meeting 2016, Cheryl Purvis
Faculty Proceedings, Presentations, Speeches and Lectures
No abstract provided.
A Mutation In Ltbp2 Causes Congenital Glaucoma In Domestic Cats (Felis Catus), Markus H. Kuehn, Koren A. Lipsett, Marilyn Menotti-Raymond, S. Scott Whitmore, Todd E. Scheetz, Victor A. David, Stephen J. O'Brien, Zhongyuan Zhao, Jackie K. Jens, Elizabeth M. Snella, N. Matthew Ellinwood, Gillian J. Mclellan
A Mutation In Ltbp2 Causes Congenital Glaucoma In Domestic Cats (Felis Catus), Markus H. Kuehn, Koren A. Lipsett, Marilyn Menotti-Raymond, S. Scott Whitmore, Todd E. Scheetz, Victor A. David, Stephen J. O'Brien, Zhongyuan Zhao, Jackie K. Jens, Elizabeth M. Snella, N. Matthew Ellinwood, Gillian J. Mclellan
Biology Faculty Articles
The glaucomas are a group of diseases characterized by optic nerve damage that together represent a leading cause of blindness in the human population and in domestic animals. Here we report a mutation in LTBP2 that causes primary congenital glaucoma (PCG) in domestic cats. We identified a spontaneous form of PCG in cats and established a breeding colony segregating for PCG consistent with fully penetrant, autosomal recessive inheritance of the trait. Elevated intraocular pressure, globe enlargement and elongated ciliary processes were consistently observed in all affected cats by 8 weeks of age. Varying degrees of optic nerve damage resulted by …
Science Alive!: Connecting With Elementary Students Through Science Exploration, Aarti Raja, Emily F. Schmitt Lavin, Tamara Gali, Kaitlin Donovan
Science Alive!: Connecting With Elementary Students Through Science Exploration, Aarti Raja, Emily F. Schmitt Lavin, Tamara Gali, Kaitlin Donovan
Biology Faculty Articles
A novel program called Science Alive! was developed by undergraduate faculty members, K–12 school teachers, and undergraduate students to enrich science, technology, engineering, and mathematics (STEM) literacy at community schools located near the university. The ultimate goal of the program is to bolster the scientific knowledge and appreciation of local area students and community members and serve as a model for similar programs. Through the program, we observed that elementary school students made gains toward learning their grade-level science curricula after a hands-on learning experience and had fun doing these hands-on activities. Through the program, undergraduate students, working with graduate …
Effect Of Westernization On Oral Health Among College Students Of Udaipur City, India, Piyush Pujara, Neeraj Sharma, Rujul Jayeshkumar Parikh, Maitri Shah, Shachi Parikh, Vivek Vadera, Manpreet Kaur, Isha Makkar, Mayur Parmar, Pratik Rupakar, Shrikant Patel
Effect Of Westernization On Oral Health Among College Students Of Udaipur City, India, Piyush Pujara, Neeraj Sharma, Rujul Jayeshkumar Parikh, Maitri Shah, Shachi Parikh, Vivek Vadera, Manpreet Kaur, Isha Makkar, Mayur Parmar, Pratik Rupakar, Shrikant Patel
HPD Articles
BACKGROUND: There is overwhelming evidence that periodontal disease and dental caries affect the majority of populations and that western culture and lifestyle may have a profound influence on oral health, especially in adults. The present study was performed to determine the effect of westernization on the oral health of college students of Udaipur City, Rajasthan. METHODS: A descriptive cross-sectional study was conducted among students attending various professional and non-professional bachelor's degree colleges of Udaipur City, Rajasthan, India, from March 2013 to May 2013. Eight hundred students were selected based on a two-stage random sampling procedure. Westernization was assessed by a …