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Articles 1 - 30 of 59
Full-Text Articles in Life Sciences
Cocoa Polyphenols Modulate The Fecal Microbiome In A Mouse Model Of Colitis, Independent Of Basal Diet And Colon Inflammation, Abby D. Benninghoff
Cocoa Polyphenols Modulate The Fecal Microbiome In A Mouse Model Of Colitis, Independent Of Basal Diet And Colon Inflammation, Abby D. Benninghoff
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Chronic inflammation increases the risk of developing multiple chronic diseases, including cancer. The risk of developing colorectal cancer (CRC) specifically is increased in individuals who suffer from colitis, a characteristic of Inflammatory Bowel Disease (IBD). Diet is another risk factor for developing CRC, particularly an inflammation-promoting Western-type diet. Thus, supplementing a Western diet with functional foods containing anti-inflammatory polyphenols is a potential approach to decreasing CRC risk by reducing gut inflammation and altering gut microbiome profile. This study aimed to determine the effects of cocoa polyphenol (CP) supplementation on inflammation status and microbiome profile before, during, and after colitis when …
Lead Bioaccessibility And Commonly Measured Soil Characteristics (Detroit, Mi, Usa) – Phase 1, Sabrina R. Good, Allison R. Harris, Patrick Crouch, Conor T. Gowan, William D. Shuster, Shawn P. Mcelmurry
Lead Bioaccessibility And Commonly Measured Soil Characteristics (Detroit, Mi, Usa) – Phase 1, Sabrina R. Good, Allison R. Harris, Patrick Crouch, Conor T. Gowan, William D. Shuster, Shawn P. Mcelmurry
Open Data at Wayne State
Contaminated urban soil is one of the major contributors to child Pb exposure. To gain a better understanding of Pb risk in urban areas, composite samples were collected from 142 residential, privately owned, parcels in Detroit, Hamtramck, and Highland Park, Michigan, with approval from the property owners. The proximity of soil sampling and former smelter locations were also reported. Sample were collected from areas covered with turf grass. Four samples were collected, one from each cardinal direction (north, south, east, and west), 20 cm from an aluminum tent stake driven into the center of the sampling site. Soils were collected …
Quantitative Raman Analysis Of Human Blood Serum Of Glaucoma Patients Supplemented With Macular Pigment Carotenoids., Joy Udensi, Ekaterina Loskutova, James Loughman, Hugh J. Byrne
Quantitative Raman Analysis Of Human Blood Serum Of Glaucoma Patients Supplemented With Macular Pigment Carotenoids., Joy Udensi, Ekaterina Loskutova, James Loughman, Hugh J. Byrne
Datasets
Carotenoids have been widely studied for their high dietary, antioxidant, and vision protection roles in the human body. Blood contains all major dietary carotenoids and hence presents as a suitable and efficient substrate for the estimation of dietary carotenoids in vivo. Following the 18-month supplementation of open angle glaucoma patients with macula pigment carotenoids (Lutein, Zeaxanthin and Meso-Zeaxanthin) in the European Nutrition in Glaucoma Management (ENIGMA) trial, Raman spectroscopic analysis of the pre-supplementation baseline and 18-month supplemented blood serum carotenoids from participants was carried out, to investigate the systemic impact of supplementation in the blood and explore a more direct …
Heterochronic Serum Proteins, Jeffrey Mason
Heterochronic Serum Proteins, Jeffrey Mason
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Mechanism of ovarian-dependent enhancement of health and longevity in postreproductive female mice
Precision Medicine, Ancestry, Genetics And Race, Lucio Miele
Precision Medicine, Ancestry, Genetics And Race, Lucio Miele
School of Medicine Faculty Publications
DiscoverBMB, March 25 - 28, 2023, Seattle, WA
Effects Of Pregnancy And Progesterone On Atrial Fibrillation, Heloisa M. Rutigliano
Effects Of Pregnancy And Progesterone On Atrial Fibrillation, Heloisa M. Rutigliano
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Atrial Fibrillation (AF) is the most common cardiac arrythmia in adults with likely sex-specific risk factors. Female sex hormones may be important in modulating risk for atrial fibrillation. We hypothesize that pregnancy and progesterone (P4), a hormone found in high levels during pregnancy with abrupt withdrawal immediately after parturition, modulates AF susceptibility in female goats. Cardiac specific TGF-?1 transgenic female goats and age-matched wild-type (WT) female goats were utilized. Pacemakers were implanted in all animals for continuous arrhythmia monitoring and AF inducibility. AF inducibility was evaluated using 5 separate 10 s bursts of atrial pacing (160 - 200 ms). In …
Dynamic Fecal Microbiota Transfer From Mice With Western Diet-Induced Severe Colitis And Colon Tumorigenesis Did Not Exacerbate Colitis Symptoms Or Colon Tumorigenesis In Recipient Mice Fed Either The Ain93g Diet Or The Total Western Diet, Abby D. Benninghoff
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Consumption of the total Western diet (TWD) in mice has been shown to increase gut inflammation, promote colon tumorigenesis, and alter the fecal microbiome composition in mice as com-pared to mice fed a healthy diet, AIN93G (AIN). However, it is unclear whether the gut micro-biome contributes directly to colitis-associated CRC in this model. The objective of this study was to determine whether dynamic fecal microbiota transfer (FMT) from host mice fed either AIN or TWD basal diets would alter colitis symptoms or colitis-associated CRC in recipient mice, which were fed either AIN or TWD directly using a 2x2 factorial experiment …
Abaloparatide, Miis Akel, Mayur Parmar
Bazedoxifene, Parth M. Raina, Mayur Parmar
Romosozumab, Kristina Krupa, Mayur Parmar, Linda F. Delo
Romosozumab, Kristina Krupa, Mayur Parmar, Linda F. Delo
HPD Articles
No abstract provided.
Dietary Supplementation With Black Raspberries Altered The Gut Microbiome Composition In A Mouse Model Of Colitis-Associated Colorectal Cancer, Although With Differing Effects For A Healthy Versus A Western Basal Diet, Abby D. Benninghoff
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Black raspberries (BRB) are rich in anthocyanins with purported anti-inflammatory properties. However, it is not known whether dietary supplementation would ameliorate Western-diet enhanced gut inflammation and colon tumorigenesis. We employed a mouse model of colitis-associated colorectal cancer (CAC) to determine the effects of dietary supplementation with 5 to 10% (w/w) whole, freeze-dried BRB in male C57BL/6J mice fed either a standard healthy diet (AIN93G) or the total Western diet (TWD). In a pilot study, BRB suppressed colitis and colon tumorigenesis while also shifting the composition of the fecal microbiome in favor of taxa with purported health benefits, including Bifidobacteria pseudolongum. …
Small Interfering Rna (Sirna)-Based Therapy, Inderbir S. Padda, Arun U. Mahtani, Mayur S. Parmar
Small Interfering Rna (Sirna)-Based Therapy, Inderbir S. Padda, Arun U. Mahtani, Mayur S. Parmar
HPD Articles
No abstract provided.
Golimumab, Inderbir S. Padda, Rajat Bhatt, Mayur S. Parmar
Golimumab, Inderbir S. Padda, Rajat Bhatt, Mayur S. Parmar
HPD Articles
No abstract provided.
Sodium-Glucose Transport Protein 2 (Sglt2) Inhibitors, Inderbir S. Padda, Arun U. Mahtani, Mayur S. Parmar
Sodium-Glucose Transport Protein 2 (Sglt2) Inhibitors, Inderbir S. Padda, Arun U. Mahtani, Mayur S. Parmar
HPD Articles
No abstract provided.
Reeling In New Antibiotics: Synthesis And Antimicrobial Susceptibility Testing Of Zinc-Binding Clavanins From Styela Clava (Sea Squirt), Eduardo Badillo-Colberg
Reeling In New Antibiotics: Synthesis And Antimicrobial Susceptibility Testing Of Zinc-Binding Clavanins From Styela Clava (Sea Squirt), Eduardo Badillo-Colberg
Honors Scholar Theses
Clavanins have been a quite rarely studied antimicrobial peptide (AMP) family. Though the data in the few studies published on the matter and in theoretical experimental data presented by the Wang lab in their peptide library creation [14], in that the members of this family could potentially be quite effective novel antimicrobial candidates. Among those that have been targets of studies, Clavanin A has been at the forefront of this endeavor of finding effective novel antimicrobial peptides[14]. In these aforementioned studies, Clavanin A has been shown to be quite effective against many different bacterial strains, which begs the question as …
Biosimilars Use In Medicine For Inflammatory Diseases, Inderbir S. Padda, Rajat Bhatt, Obaid Rehman, Mayur S. Parmar
Biosimilars Use In Medicine For Inflammatory Diseases, Inderbir S. Padda, Rajat Bhatt, Obaid Rehman, Mayur S. Parmar
HPD Articles
No abstract provided.
Improved De Novo Alignment Of A Girardia Dorotocephala Ma-C2 (2n = 24) Transcriptome, Labib Rouhana, J F. Ryan, Eugene M. P. Almazan
Improved De Novo Alignment Of A Girardia Dorotocephala Ma-C2 (2n = 24) Transcriptome, Labib Rouhana, J F. Ryan, Eugene M. P. Almazan
Biological Sciences Faculty Publications
Improved De novo alignment of a Girardia dorotocephala MA-C2 (2n = 24) transcriptome.
Covid (Sars-Cov-2) Vaccine, Inderbir S. Padda, Mayur S. Parmar
Covid (Sars-Cov-2) Vaccine, Inderbir S. Padda, Mayur S. Parmar
HPD Articles
No abstract provided.
Aducanumab, Inderbir S. Padda, Mayur S. Parmar
Apremilast, Inderbir S. Padda, Rajat Bhatt, Mayur S. Parmar
Apremilast, Inderbir S. Padda, Rajat Bhatt, Mayur S. Parmar
HPD Articles
No abstract provided.
Pegloticase, Inderbir S. Padda, Rajat Bhatt, Mayur S. Parmar
Pegloticase, Inderbir S. Padda, Rajat Bhatt, Mayur S. Parmar
HPD Articles
No abstract provided.
Tofacitinib, Inderbir S. Padda, Rajat Bhatt, Mayur S. Parmar
Tofacitinib, Inderbir S. Padda, Rajat Bhatt, Mayur S. Parmar
HPD Articles
No abstract provided.
Upadacitinib, Inderbir S. Padda, Rajat Bhatt, Mayur S. Parmar
Upadacitinib, Inderbir S. Padda, Rajat Bhatt, Mayur S. Parmar
HPD Articles
No abstract provided.
Lenvatinib, Inderbir S. Padda, Mayur S. Parmar
Obeticholic Acid, Kristina Krupa, Vera Hapshy, Hiep Nguyen, Mayur S. Parmar
Obeticholic Acid, Kristina Krupa, Vera Hapshy, Hiep Nguyen, Mayur S. Parmar
HPD Articles
No abstract provided.
Sars-Cov-2 Exposure In Wild White-Tailed Deer (Odocoileus Virginianus), Jeffrey C. Chandler, Sarah N. Bevins, Jeremy W. Ellis, Timothy J. Linder, Rachel M. Tell, Melinda Jenkins-Moore, J. Jeffrey Root, Julianna B. Lenoch, Suelee Robbe-Austerman, Thomas J. Deliberto, Tom Gidlewski, Mia Kim Torchetti, Susan A. Shriner
Sars-Cov-2 Exposure In Wild White-Tailed Deer (Odocoileus Virginianus), Jeffrey C. Chandler, Sarah N. Bevins, Jeremy W. Ellis, Timothy J. Linder, Rachel M. Tell, Melinda Jenkins-Moore, J. Jeffrey Root, Julianna B. Lenoch, Suelee Robbe-Austerman, Thomas J. Deliberto, Tom Gidlewski, Mia Kim Torchetti, Susan A. Shriner
USDA Wildlife Services: Staff Publications
Widespread human SARS-CoV-2 infections combined with human–wildlife interactions create the potential for reverse zoonosis from humans to wildlife. We targeted white-tailed deer (Odocoileus virginianus) for serosurveillance based on evidence these deer have angiotensin-converting enzyme 2 receptors with high affinity for SARS-CoV-2, are permissive to infection, exhibit sustained viral shedding, can transmit to conspecifics, exhibit social behavior, and can be abundant near urban centers. We evaluated 624 prepandemic and postpandemic serum samples from wild deer from four US states for SARS-CoV-2 exposure. Antibodies were detected in 152 samples (40%) from 2021 using a surrogate virus neutralization test. A subset of samples …
Human Papilloma Virus Vaccine, Lucia Soca Gallego, Alvio Dominguez, Mayur S. Parmar
Human Papilloma Virus Vaccine, Lucia Soca Gallego, Alvio Dominguez, Mayur S. Parmar
HPD Articles
No abstract provided.
Flucytosine, Inderbir S. Padda, Mayur S. Parmar
Reserpine, Michelle Cheung, Mayur S. Parmar
Omega-3 Fatty Acids, Kristina Krupa, Kristina Fritz, Mayur S. Parmar
Omega-3 Fatty Acids, Kristina Krupa, Kristina Fritz, Mayur S. Parmar
HPD Articles
No abstract provided.