Open Access. Powered by Scholars. Published by Universities.®
- Publication
Articles 1 - 3 of 3
Full-Text Articles in Life Sciences
Assessment Of Human Cd4+ And Cd8+ T Lymphocyte Responses In Experimental Viral Vaccine Studies, Alan Rothman, Y. Yamada, Julie Jameson, John Cruz, Kim West, Sharone Green, Francis Ennis
Assessment Of Human Cd4+ And Cd8+ T Lymphocyte Responses In Experimental Viral Vaccine Studies, Alan Rothman, Y. Yamada, Julie Jameson, John Cruz, Kim West, Sharone Green, Francis Ennis
Alan Rothman
The traditional in vitro correlate of immunological protection is the induction by a vaccine of neutralizing antibodies against the virus. It was formerly assumed that protection induced by a vaccine was solely due to neutralizing antibodies. Neutralizing antibodies are potent in the prevention of certain diseases, but virus-specific CD4+ T helper cells aid in the proliferation of specific antigen-triggered B cells to make antibodies. CD8+ T cells are responsible for eliminating virus-infected cells during viral illness, and may act as a second line of defence by becoming activated and eliminating any cells that become infected despite the presence of neutralizing …
Assessment Of Human Cd4+ And Cd8+ T Lymphocyte Responses In Experimental Viral Vaccine Studies, Alan Rothman, Y. Yamada, Julie Jameson, John Cruz, Kim West, Sharone Green, Francis Ennis
Assessment Of Human Cd4+ And Cd8+ T Lymphocyte Responses In Experimental Viral Vaccine Studies, Alan Rothman, Y. Yamada, Julie Jameson, John Cruz, Kim West, Sharone Green, Francis Ennis
Sharone Green
The traditional in vitro correlate of immunological protection is the induction by a vaccine of neutralizing antibodies against the virus. It was formerly assumed that protection induced by a vaccine was solely due to neutralizing antibodies. Neutralizing antibodies are potent in the prevention of certain diseases, but virus-specific CD4+ T helper cells aid in the proliferation of specific antigen-triggered B cells to make antibodies. CD8+ T cells are responsible for eliminating virus-infected cells during viral illness, and may act as a second line of defence by becoming activated and eliminating any cells that become infected despite the presence of neutralizing …
Inhibitory Effect Of Monocyte Reactive Antibodies On Monocyte Chemotaxis In Systemic Lupus Erythematosus, Gyula Szegedi, Katalin Lukacs, E. Bodolay, L. Gulacsi, Ildiko Sonkoly, Gyongyi Szabo, J. Szollosi
Inhibitory Effect Of Monocyte Reactive Antibodies On Monocyte Chemotaxis In Systemic Lupus Erythematosus, Gyula Szegedi, Katalin Lukacs, E. Bodolay, L. Gulacsi, Ildiko Sonkoly, Gyongyi Szabo, J. Szollosi
Gyongyi Szabo
Presence of different types of autoantibodies is a basic feature of systemic lupus erythematosus (SLE). Though monocytes, macrophages play an important role in cellular immunity, autoantibodies against monocytes have not been sufficiently studied. The authors used automatic fluorochromatic assay to detect monocyte reactive autoantibodies in the sera of SLE patients. Of SLE 35.5% sera showed complement-mediated monocytotoxic activity against healthy monocytes. Monocyte reactive SLE sera as well as monoclonal antibodies against human monocytes inhibited chemotaxis of control monocytes. The results suggest that monocyte reactive autoantibodies may play a role in the decreased monocyte number and defective monocyte functions observed in …