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The Role Of Gaba In Reproductive Neuroendocrine Systems, Robert Carter Mcree
The Role Of Gaba In Reproductive Neuroendocrine Systems, Robert Carter Mcree
Theses and Dissertations in Biomedical Sciences
Local gamma-amino butyric acid (GABA) neurons in the hypothalamus can modulate the luteinizing hormone releasing hormone (LHRH) pulse generating system.
Two animal models (intact and ovariectomized rats) were used to determine the nature of modulation of LHRH release by GABA. The experiment determined the release of LHRH, serotonin (5-HT), and 5-hydroxyindole acetic acid (5-HIAA) during two hormonal states with each model. In the intact rat the proestrus and estrus states were examined, and in the ovariectomized rat in-vitro release was determined with (OVX2) and without (OVX) estradiol treatment.
In-vivo experiments studied the effect of stimulation of GABA receptors …