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- A process termed mechanotransduction. Through cell-ECM focal adhesions (1)
- Aid in the advancement of both tissue engineering and cancer treatment research. (1)
- And polyacrylamide gels containing fluorescent beads. The mobility of integrin on the different substrates was assessed using fluorescent recovery after photo-bleaching (FRAP) and analyzed along with cell traction force measurements. These studies serve to further the understanding of our knowledge of integrin and its role in mechanotransduction and migration. It will (1)
- Angiogenesis (1)
- AngiognesisThe formation of new vasculature is an essential process (1)
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- Anthocyanins (1)
- Blacklegged (deer) tick (1)
- Breast cancer (1)
- But can also be utilized by cancerous cells. Angiogenesis requires the directed migration of the endothelial cells lining the nascent blood vessels. This process is largely mediated by integrin (1)
- Candida albicans (1)
- Cardiac (1)
- Cell migration (1)
- Cilia (1)
- Ciliopathy (1)
- Climate change (1)
- Congenital heart disease (1)
- Controlled study (1)
- Dense tissue (1)
- Early detection (1)
- ErbB (1)
- Focal adhesion (1)
- HUVECs (1)
- Hedgehog (1)
- Host immunity (1)
- Host-pathogen interactions (1)
- Image-based risk assessment (1)
- Integrin (1)
- Integrin mediates the signaling both into and out of the cell (1)
- Ixodes scapularis (1)
- Lyme disease (1)
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Articles 1 - 8 of 8
Full-Text Articles in Life Sciences
A Quantitative Visualization Tool For The Assessment Of Mammographic Risky Dense Tissue Types, Margaret R. Mccarthy
A Quantitative Visualization Tool For The Assessment Of Mammographic Risky Dense Tissue Types, Margaret R. Mccarthy
Electronic Theses and Dissertations
Breast cancer is the second most occurring cancer type and is ranked fifth in terms of mortality. X-ray mammography is the most common methodology of breast imaging and can show radiographic signs of cancer, such as masses and calcifcations. From these mammograms, radiologists can also assess breast density, which is a known cancer risk factor. However, since not all dense tissue is cancer-prone, we hypothesize that dense tissue can be segregated into healthy vs. risky subtypes. We propose that risky dense tissue is associated with tissue microenvironment disorganization, which can be quantified via a computational characterization of the whole breast …
Primary Cilia Of The Cardiac Neural Crest & Hedgehog-Mediated Mechanisms Of Congenital Heart Disease, Lindsey A. Fitzsimons
Primary Cilia Of The Cardiac Neural Crest & Hedgehog-Mediated Mechanisms Of Congenital Heart Disease, Lindsey A. Fitzsimons
Electronic Theses and Dissertations
Elimination of primary cilia in cardiac neural crest cell (CNCC) progenitors is hypothesized to cause a variety of congenital heart defects (CHDs), including atrioventricular septal defects, and malformations of the developing cardiac outflow tract. We present an in vivo model of CHD resulting from the conditional elimination of primary cilia from CNCC using multiple, Wnt1:Cre-loxP, neural crest-specific systems, targeting two distinctive, but critical, primary cilia structural genes: Intraflagellar transport protein 88 (Ift88) or kinesin family member 3A (Kif3a). CNCC loss of primary cilia leads to widespread CHD, where homozygous mutant embryos (MUT) display a variety of outflow tract malformations, septation …
Cpap-Compliance Of Aging Individuals With Obstructive Sleep Apnea With Or Without Mild Cognitive Impairment, Bailey Carter
Cpap-Compliance Of Aging Individuals With Obstructive Sleep Apnea With Or Without Mild Cognitive Impairment, Bailey Carter
Honors College
With approximately 20% of Americans affected by obstructive sleep apnea (OSA), and over 30% of sleep apneic patients non-compliant with the most common form of treatment, CPAP (Continuous Positive Airway Pressure), the proposed study looks to investigate the relationship between OSA, CPAP-compliance, and cognitive decline associated with many aging-related neurodegenerative diseases [1, 2]. Our group has performed in-home sleep studies using a patented, sensor mattress-sheet device, and standard actigraphy. Demographics including a questionnaire on OSA compliance and neurocognitive tests were administered to participants between 62 and 90 years of age. Cognitive decline meeting criteria for MCI (Mild Cognitive Impairment, the …
Blacklegged Tick (Ixodes Scapularis) Distribution In Maine, Usa, As Related To Climate Change, White-Tailed Deer, And The Landscape, Susan P. Elias
Blacklegged Tick (Ixodes Scapularis) Distribution In Maine, Usa, As Related To Climate Change, White-Tailed Deer, And The Landscape, Susan P. Elias
Electronic Theses and Dissertations
Lyme disease is caused by the bacterial spirochete Borrelia burgdorferi, which is transmitted through the bite of an infected blacklegged (deer) tick (Ixodes scapularis). Geographic invasion of I. scapularis in North America has been attributed to causes including 20th century reforestation and suburbanization, burgeoning populations of the white-tailed deer (Odocoileus virginianus) which is the primary reproductive host of I. scapularis, tick-associated non-native plant invasions, and climate change. Maine, USA, is a high Lyme disease incidence state, with a history of increasing I. scapularis abundance and northward range expansion. This thesis addresses the question: “To …
The Effect Of Wild Blueberry Bioactives On Endothelial Cell Migration And Angiogenesis: An In Vitro Mechanistic, Genomic And Proteomic Approach, Panagiotis Tsakiroglou
The Effect Of Wild Blueberry Bioactives On Endothelial Cell Migration And Angiogenesis: An In Vitro Mechanistic, Genomic And Proteomic Approach, Panagiotis Tsakiroglou
Electronic Theses and Dissertations
The goal of this study is to investigate the effects of wild blueberry fractions (Anthocyanins and Phenolic acids) on vascular function and physiology. More specifically the potential effects of the above fractions and their combination in physiological concentrations on endothelial cell migration, angiogenesis, gene expression and proteins synthesis of markers related to the above processes. The objectives are to study whether anthocyanins, phenolic acids and their combinations (ACNs:PAs) affect: a) cell proliferation, b) speed of endothelial cell migration, c) angiogenesis, d) gene expression of genes critical for cell migration and angiogenesis such as RAC1, RHOA, AKT1, eNOS and VEGF and …
Basic Vision Research With Clinical Applications And Science Education Assessments, Andrew Wilson
Basic Vision Research With Clinical Applications And Science Education Assessments, Andrew Wilson
Electronic Theses and Dissertations
Visual Acuity (VA) examinations are one of the most commonly conducted medical assessment throughout the world. Recent advances in computer technology allows for new forms of visual assessment to be conducted. In Part I of this thesis I demonstrate the capability of an automated computer program named VISION to assess human visual acuities. Different color combinations of an object against a background emitted from a computer screen are used to examine a variety of human color vision acuities. Results indicated a large difference in acuity scores between human subjects tested with these different color combinations. A single human subject exhibits …
Dynamic Host-Pathogen Interactions Result In Fungal Epitope Unmasking, Alex Hopke
Dynamic Host-Pathogen Interactions Result In Fungal Epitope Unmasking, Alex Hopke
Electronic Theses and Dissertations
Molecular camouflage is used by a diverse set of pathogens to disguise their identity and avoid recognition by protective host receptors. The opportunistic fungal pathogen Candida albicans is a good example, as it masks the inflammatory component β-glucan in its cell wall to evade detection by the immune receptor Dectin-1. Interestingly, it has been seen that β-glucan becomes unmasked during infection in vivo, though the underlying mechanisms remained unclear. Exposure levels of this epitope may be important, as Dectin-1 mediates protection from some strains of C. albicans and alterations in the organization and composition of the Candida cell wall …
A Novel Mechanism For Mechanosensing By Endothelial Cells, Jennifer Macdowell
A Novel Mechanism For Mechanosensing By Endothelial Cells, Jennifer Macdowell
Honors College
The formation of new vasculature is an essential process, but can also be utilized by cancerous cells. Angiogenesis requires the directed migration of the endothelial cells lining the nascent blood vessels. This process is largely mediated by integrin, which plays a key role in the interplay between sensing a force in the extracellular matrix (ECM) and transducing this signal, a process termed mechanotransduction. Through cell-ECM focal adhesions, integrin mediates the signaling both into and out of the cell, promoting growth of focal adhesions and subsequent cell spreading and migration. In order to study focal adhesion dynamics related to force, we …