Life Sciences Commons^™

Il-10 And Alveolar Bone Loss, Abdulaziz Saud Al-Rasheed

Loma Linda University Electronic Theses, Dissertations & Projects

Interleukin-10 (IL-10) is a cytokine with anti-inflammatory activities. IL-10 knockout (KO) mice exhibit severe intestinal inflammation in the presence of normal gut flora. We hypothesized that IL-10 KO mice would also be susceptible to inflammatory periodontal disease resulting in alveolar bone loss (ABL). The purpose of this study was to compare naturally occurring ABL in IL-10 KO and wild type (WT) mice. Twelve IL-10 KO and 12 WT mice, age-(7 months) and sex-(male) matched, were used. Half of the mice were on 129/SvEv and half on C57BL/6J background. Animal heads were defleshed and treated to remove all organic material. ABL …

A Correlational Analysis Of Anthropometric Measures And Selected Blood, Immune And Endocrine Indices In Adult Males, Janet Tracey Peterson

Loma Linda University Electronic Theses, Dissertations & Projects

Over the past few decades it has become apparent that increased body weight, specifically body fat, coupled with a sedentary lifestyle is associated with an increased risk for chronic disorders such as cardiovascular disease and diabetes. Researchers are now re-directing their focus on determining the cause of these relationships from an epidemiological view to a more biological or physiological standpoint. The purpose of this cross sectional study was to examine associations among obesity, physical activity and select immune, endocrine and metabolic parameters identified as risk factors for several chronic conditions. Ninety-one healthy males between the ages of 19 and 45 …

Linder-Aronson S Analysis Using Rhinomanometry And Newtom, Noel Moser

Loma Linda University Electronic Theses, Dissertations & Projects

Investigations into the effects of airway patency on craniofacial development are essential to ensure that interceptive orthodontic treatment provides the maximum benefit to the patient. The aims of this study were to (1) compare the size of the nasopharyngeal airway space on lateral cephalometric and 3D volumetric radiographs to determine if volumetric scans can be of greater diagnostic value than a lateral cephalometric film in determining the degree of airway blockage or patency and (2) to examine the correlation between functional airway resistance, as evaluated by rhinomanometry, and radiographic constriction due to nasal turbinate and adenoid size.

Twenty-eight subjects from …

Enhancement Of Anti-Hiv-1 Ribozyme Activities By Rev Binding And Multimerization, Yuksel Yildiz

Loma Linda University Electronic Theses, Dissertations & Projects

To effectively apply hammerhead ribozymes as therapeutic agents it is necessary to co-localize them with the desired target. Human immunodeficiency virus type1 (HIV- 1) infectivity is dependent on env gene expression. HIV-1 Rev protein binds to a higher ordered RNA structure within the env transcript termed the Rev Binding Element (RBE). In anti-HIV gene therapy employing ribozymes to increase the co-localization of anti- HIV ribozymes with target HIV mRNAs, it has been proposed that when the native HIV- 1 RBE is appended to a ribozyme as a decoy molecule, simultaneous binding of Rev monomers to the RBE sequences in both …