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Dna Double Strand Breaks: To Repair, Or Not To Repair, Susiyan Jiang
Dna Double Strand Breaks: To Repair, Or Not To Repair, Susiyan Jiang
NYMC Student Theses and Dissertations
DNA damages that cause double-strand breaks (DSBs) to the chromosome are most harmful. Subsequent choices have critical consequences for cell fate. Without repair, cells will face certain death. Low-fidelity repair will introduce mutations that could transform the cells, leading to carcinogenesis.
How cells make the decision is not well-understood. A single DSB can lead to apoptosis for some cells, whereas others can repair up to 25 DSBs and survive. It has been postulated that decision to repair DSBs is a stochastic process.
In the nucleus, DSBs elicit a cascade of signaling events that require the recognition, protection, processing, and subsequent …