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Primary Myoblasts From Intrauterine Growth-Restricted Fetal Sheep Exhibit Intrinsic Dysfunction Of Proliferation And Differentiation That Coincides With Enrichment Of Inflammatory Cytokine Signaling Pathways, Robert J. Posont, Micah S. Most, Caitlin Cadaret, Eileen Marks-Nelson, Kiristen A. Beede, Sean W. Limesand, Ty B. Schmidt, Jessica L. Petersen, Dustin T. Yates
Primary Myoblasts From Intrauterine Growth-Restricted Fetal Sheep Exhibit Intrinsic Dysfunction Of Proliferation And Differentiation That Coincides With Enrichment Of Inflammatory Cytokine Signaling Pathways, Robert J. Posont, Micah S. Most, Caitlin Cadaret, Eileen Marks-Nelson, Kiristen A. Beede, Sean W. Limesand, Ty B. Schmidt, Jessica L. Petersen, Dustin T. Yates
Department of Animal Science: Faculty Publications
Intrauterine growth restriction (IUGR) is linked to lifelong reductions in muscle mass due to intrinsic functional deficits in myoblasts, but the mechanisms underlying these deficits are not known. Our objective was to determine if the deficits were associated with changes in inflammatory and adrenergic regulation of IUGR myoblasts, as was previously observed in IUGR muscle. Primary myoblasts were isolated from IUGR fetal sheep produced by hyperthermia-induced placental insufficiency (PI-IUGR; n = 9) and their controls (n = 9) and from IUGR fetal sheep produced by maternofetal inflammation (MI-IUGR; n = 6) and their …