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Full-Text Articles in Life Sciences
A Robust Measure Of Correlation Between Two Genes On A Microarray, Johanna S. Hardin, Aya Mitani '06, Leanne Hicks, Brian Vankoten
A Robust Measure Of Correlation Between Two Genes On A Microarray, Johanna S. Hardin, Aya Mitani '06, Leanne Hicks, Brian Vankoten
Pomona Faculty Publications and Research
Background
The underlying goal of microarray experiments is to identify gene expression patterns across different experimental conditions. Genes that are contained in a particular pathway or that respond similarly to experimental conditions could be co-expressed and show similar patterns of expression on a microarray. Using any of a variety of clustering methods or gene network analyses we can partition genes of interest into groups, clusters, or modules based on measures of similarity. Typically, Pearson correlation is used to measure distance (or similarity) before implementing a clustering algorithm. Pearson correlation is quite susceptible to outliers, however, an unfortunate characteristic when dealing …
A Model Of Dna Knotting And Linking, Erica Flapan, Dorothy Buck
A Model Of Dna Knotting And Linking, Erica Flapan, Dorothy Buck
Pomona Faculty Publications and Research
We present a model of how DNA knots and links are formed as a result of a single recombination event, or multiple rounds of (processive) recombination events, starting with an unknotted, unlinked, or a (2,m)-torus knot or link substrate. Given these substrates, according to our model all DNA products of a single recombination event or processive recombination fall into a single family of knots and links.