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In-Vitro And In-Vivo Effects Of 8 Chemotherapeutants On The Oyster Parasite Perkinsus-Marinus (Mackin, Owen, And Collier), Gustavo W. Calvo, Eugene M. Burreson

VIMS Articles

Eight therapeutants were tested for in vitro inhibition of Perkinsus marinus (Mackin, Owen, and Collier) enlargement and in vivo control of established infections. In addition, acute toxicity of six anticoccidials to oysters was determined. For in vitro experiments 0.2 ml aliquots of infected hemolymph were exposed to 5 concentrations (100 mg/l, 10 mg/l, 1 mg/l, 0.1 mg/l and 0.01 mg/1) of amprolium, arprinocid, cycloheximide, lasalocid, malachite green, monensin, sulfadimethoxine, and a potentiated sulfadimethoxine. Exposure lasted 1 day and was followed by incubation in fluid thioglycollate medium. Lasalocid and malachite green were the most effective compounds, showing significant anti-P. marinus activity …